Hepatitis D Antibodies, Total (Sendout)

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General Information

Lab Name
Hepatitis D Antibodies, Total
Lab Code
RHEPDA
Epic Ordering
Hepatitis D Antibodies, Total (Sendout)
External Test Id
AHDV
Description

Useful for:

  • Detection of hepatitis D virus (HDV)-specific total antibodies (combined IgG and IgM) in human serum
  • Diagnosis of concurrent HDV infection in patients with fulminant acute hepatitis B virus (HBV) infection (acute coinfection), chronic HBV infection (chronic coinfection), or acute exacerbation of known chronic HBV infection (HDV superinfection)
References
  1. Mayo Clinic Laboratories Clinical & Interpretive Information: Hepatitis D Virus Total Antibodies
Synonyms
AHDV, Anti-HDV, Delta Hepatitis, HDV Antibodies, Hepatitis Delta Antibodies
Components
Code Name
RHDAB Hepatitis D Ab (Total)

Interpretation

Method

Enzyme Immunoassay (EIA)

Reference Range
See individual components
Ref. Range Notes

Reference Values: Negative

Interpretation:

This assay detects the presence of hepatitis D virus (HDV)-specific total (combined IgG and IgM) antibodies in serum.

Negative results indicate the absence of HDV infection and no past exposure to HDV.

Equivocal results indicate borderline level of anti-HDV total antibodies. Repeat testing in 1 to 2 weeks is recommended to determine the definitive HDV infection status.

Positive results usually indicate one of the following conditions: 1) simultaneous acute or chronic coinfection with hepatitis B virus (HBV) and HDV, 2) acute HDV infection in patients with known chronic HBV infection (ie, HDV superinfection), or 3) resolved HDV infection. Results should be correlated with medical history and clinical findings.

Interferences and Limitations

Cautions:

Negative results may not rule-out hepatitis D virus (HDV) infection during the early phase of infection or in immunocompromised patients who have delayed or inadequate immune response.

False-positive results may be due to cross-reactive antibodies from other viral infection or underlying illnesses. Positive result should be correlated with the patient's clinical history, physical examination findings, and risk factors for HDV infection.

Performance characteristics have not been established for the following specimen characteristics:

  • Grossly icteric (total bilirubin level of >20 mg/dL)
  • Grossly lipemic (triolein level of >3000 mg/dL)
  • Grossly hemolyzed (hemoglobin level of >500 mg/dL)
  • Containing particulate matter
  • Cadaveric specimens
Guidelines

Ordering & Collection

Specimen Type
Blood
Collection

Collect 3mL blood in RED TOP or GOLD SST tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Freeze serum at -20°C while awaiting shipment. Transport samples on dry ice.

Stability: Frozen (preferred): 30 days; Refrigerated: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Quantity
requested: 1 mL serum
minimum: 0.5 mL serum

Processing

Processing

Centrifuge and transfer serum to a separate plastic vial within 2 hours of collection. Freeze serum at -20°C.

Sendouts:

  • Order Mayo Test: AHDV.
  • Interfaced: Yes.

Stability: Frozen (preferred): 30 days; Refrigerated: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Performance

LIS Dept Code
Sendouts Mayo Lab (FZ) (MAFZ)
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901

Frequency
Performed: Varies. Maximum Laboratory Time: 7 days
Available STAT?
No

Billing & Coding

CPT codes
86692
LOINC
40727-0
Interfaced Order Code
UOW3967