Porphobilinogen, Random Urine

General Information

Lab Name
Porphobilinogen, Random Urine
Lab Code
UPBGRG
Epic Name
Porphobilinogen, Random Urine
Description

STAT requests require approval from the Lab Med Resident. Increased urinary porphobilinogen concentration in the presence of acute clinical symptoms is consistent with a biochemical diagnosis of acute porphyria, variegate porphyria, or hereditary coproporphyria. Normal concentrations may be seen in porphyria patients who are asymptomatic at the time of collection.

Synonyms
porphyria, spot urine
Components

Interpretation

Method

Modified Mauzerall-Granick method

Reference Range
See individual components
Ref. Range Notes

The literature reference for this reference range is: Deacon AC, Elder GH. Front line tests for the investigation of suspected porphyria. J Clin Pathol 2001; 54:500-507.

Ordering & Collection

Specimen Type
Urine
Collection

RANDOM URINE: STAT specimens do not need preservative if delivered immediately to the laboratory.

RANDOM URINE: ROUTINE specimens

For specimens with 30 mL or more: add 5g sodium bicarbonate (i.e., a well-rounded teaspoon).

For specimens with less than 30 mL, pour a maximum of 10 mL a into pre-aliquotted sodium bicarbonate tube, which contains 200 mg of sodium bicarbonate.

Please note, regardless of the volume of urine, maintain a ratio of at least 2 mg sodium bicarbonate / mL urine.

Mix well. Refrigerate. Shield from light (i.e., store in a light-protected container or wrap in foil).

For 24-hour urine, see Porphobilinogen Quantitative, 24-h urine [UPBG]

Quantity
Requested: 50 mL urine
Minimum: 10 mL urine

Processing

Receiving Instructions

Mix well. Refrigerate in a dark bottle.

Misc Sendout

Performance

Lab Department
Chemistry, Harborview(CHH)
Frequency
Monday to Friday, samples received in Special Chemistry by 11AM. Weekends and holidays, approved STAT only.
Available STAT?
with approval
Performing Location(s)

Billing & Coding

CPT Codes
84110
LOINC
27382-1
Interfaced Order Code
UOW3503