2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, Random Urine (Sendout)

single page view

General Information

Lab Name
2,3 Dinor 11B Prostaglandin F2a, Random Urine (Sendout)
Lab Code
RUR23B
Epic Name
2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, Random Urine (SO)
External Test Id
23BPR
Description

Useful For: Screening for mast cell activation disorders including systemic mastocytosis. 2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is elevated in the urine of patients with systemic mastocytosis (SM). When 2,3 BPG is used in combination with Leukotriene E4 (LTE4), Random Urine (Sendout) [RURLT4] and N Methylhistamine, Random Urine (Sendout) [RURNMH], the sensitivity for SM detection increases to 90%.

    Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.

      Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated 2,3 BPG in urine.

        Patient Preparation: Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAID) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to collecting a specimen.

          Ordering Requirements: Test pre-approved for orders originating from Fred Hutch, UW Medicine, or The Vancouver Clinic Allergy Clinics (MSALL, UESALL, VANTVC). Orders from other locations require Laboratory Medicine Resident (LMR) approval.

            Ordering Note: This test is for random urine collections only. For timed collections, refer to 2,3 Dinor 11 Beta Prostaglandin F2 Alpha, 24h Urine (Sendout) [RU23BP].

            Synonyms
            11 Beta-Prostaglandin F2 Alpha, 11BPG, 2 3 11 Beta-Prostaglandin F2 Alpha, 23BPG, 23BPR, BPG2, Mastocytosis, Prostaglandin
            Components
            Code Name
            RUR23R 2,3 Dinor 11B Prostaglandin F2a, Random Urine
            RUCRER Creatinine, Random Urine

            Interpretation

            Method

            2,3-Dinor-11 Beta-Prostaglandin F2 Alpha: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Creatinine: Enzymatic Colorimetric Assay

            Reference Range
            See individual components
            Ref. Range Notes

            Reference Ranges:

            2,3-dinor 11B-Prostaglandin F2a, Random Urine: <1802 pg/mg creatinine
            Creatinine, Random Urine (> or =18 years): 16-326 mg/dL

            Interpretation: Elevated urine 2,3-dinor-11beta-prostaglandin F2 alpha is consistent with systemic mastocytosis.

            Ordering & Collection

            Specimen Type
            Urine
            Collection

            Random Urine Collection: Collect 5 mL random urine in a preservative-free collection container.

            Approval Required
            Test pre-approved for orders originating from Fred Hutch, UW Medicine, or The Vancouver Clinic Allergy Clinics (MSALL, UESALL, VANTVC). Orders from all other locations require Laboratory Medicine Resident (LMR) approval.
            Handling Instructions

            Outside Laboratories:

            • Aliquot 5 mL urine to a plastic screw-cap vial and refrigerate specimen.
            • Indicate "random collection" on the DLMP requisition.

            Stability: Refrigerated (Preferred): 14 days; Frozen: 30 days; Ambient: 8 hours.

            Quantity
            Requested: 5 mL urine
            Minimum: 4 mL urine

            Processing

            Receiving Instructions

            Transfer 5 mL urine to a plastic, screw-capped vial and refrigerate.

              Sendouts:

              • Order Mayo Test: 23BPR
              • Interfaced: Yes [Interface: 601; Worksheet: MARF]

              Stability: Refrigerated (Preferred): 14 days; Frozen: 30 days; Ambient: 8 hours.

              Misc Sendout

              Performance

              Lab Department
              Sendouts Mayo Lab (FZ)(MAFZ)
              Frequency
              Performed: Tuesday, Thursday. Report Available: 3-8 days from sample receipt at Mayo Clinical Labs.
              Available STAT?
              No
              Performing Location(s)
              Sendout Mayo Clinic Laboratories
              800-533-1710

              200 First Street Southwest
              Rochester, MN 55901
              Sendout Mayo Clinic Laboratories (Superior Drive)
              800-533-1710

              3050 Superior Drive NW
              Rochester, MN 55901

              Billing & Coding

              CPT Codes
              82570, 84150
              LOINC
              97658-9
              Interfaced Order Code
              UOW6212