Coccidioides Antibody, for follow-up, CF & ID (Sendout)

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General Information

Lab Name
Coccidiodies Ab, For Follow-up, CF & ID (Sendout)
Lab Code
RSCOCC
Epic Ordering
Coccidiodies Ab, For Follow-up, CF & ID (Sendout)
External Test Id
SCOC
Description

Useful For: Monitoring of coccidioidomycosis using serum specimens.

Ordering Guidance: Follow-up testing for known positives only. Refer to Coccidioides Antibody Initial Screen, Reflex to CF & ID (Sendout) [RCOXIS] for initial diagnostic testing.

References
Synonyms
Coccidioides antibodies by CF and ID, Coccidioides immitis, Coccidioides posadasii, Coccidioides serology, San Joaquin Valley fever, SCOC, Valley Fever
Components

Interpretation

Method

Complement Fixation (CF) and Immunodiffusion (ID)

Reference Range
See individual components
Ref. Range Notes

Reference Values:

Complement Fixation: Negative Note: If positive, results are titered.
Immunodiffusion: Negative Note: Results are reported as positive, negative, or equivocal.

Interpretation:

Complement Fixation:

Titer results of 1:2 or higher may suggest active disease; however, titers may persist for months after infection has resolved. Increasing complement fixation (CF) titer results in serial specimens are considered diagnostic of active disease.

Immunodiffusion:

The presence of IgM antibodies may be detectable within 2 weeks after the onset of symptoms; however, the antibody may be detected longer than 6 months after infection.

The presence of IgG antibodies parallels the CF antibodies and may suggest an active or a recent asymptomatic infection with Coccidioides immitis/posadasii; however, antibodies may persist after the infection has resolved.

An equivocal result (a band of nonidentity) cannot be interpreted as significant for a specific diagnosis. However, this may be an indication that a patient should be followed serologically.

Over 90% of primary symptomatic cases will be detected by combined immunodiffusion and CF testing.

Interferences and Limitations

Cautions: Antibodies (both IgM and IgG) may be present after the infection has resolved.

Guidelines

Ordering & Collection

Specimen Type
Blood
Collection

6 mL blood in GOLD SST or RED TOP tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia.

Quantity
requested: 1.8 mL serum
minimum: 1.2 mL serum

Processing

Processing

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Sendouts:

  • Order Mayo Test: SCOC.
  • Interfaced: Yes.

Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia.

Performance

LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901

Frequency
Performed: Monday - Friday. Report Available: 4-7 days.
Available STAT?
No

Billing & Coding

CPT codes
86635x3
LOINC
87435-4
Interfaced Order Code
UOW4714