Coccidioides Antibody, for follow-up, CF & ID (Sendout)
General Information
- Lab Name
- Coccidiodies Ab, For Follow-up, CF & ID (Sendout)
- Lab Code
- RSCOCC
- Epic Ordering
- Coccidiodies Ab, For Follow-up, CF & ID (Sendout)
- External Test Id
- SCOC
- Description
Useful For: Monitoring of coccidioidomycosis using serum specimens.
Ordering Guidance: Follow-up testing for known positives only. Refer to Coccidioides Antibody Initial Screen, Reflex to CF & ID (Sendout) [RCOXIS] for initial diagnostic testing.
- References
- Mayo Clinic Laboratories Clinical & Interpretive Information: Coccidioides Antibody, Complement Fixation and Immunodiffusion, Serum
- Washington State Department of Health Notifiable Conditions: Coccidioidomycosis (Valley Fever)
- Synonyms
- Coccidioides antibodies by CF and ID, Coccidioides immitis, Coccidioides posadasii, Coccidioides serology, San Joaquin Valley fever, SCOC, Valley Fever
- Components
-
Code Name RSCOCF Coccidioides Antibody by Complement Fixation RSCOCG Coccidioides IgG Antibody by Immunodiffusion RSCOCM Coccidioides IgM Antibody by Immunodiffusion
Interpretation
- Method
Complement Fixation (CF) and Immunodiffusion (ID)
- Reference Range
- See individual components
- Ref. Range Notes
Reference Values:
Complement Fixation: Negative Note: If positive, results are titered. Immunodiffusion: Negative Note: Results are reported as positive, negative, or equivocal. Interpretation:
Complement Fixation:
Titer results of 1:2 or higher may suggest active disease; however, titers may persist for months after infection has resolved. Increasing complement fixation (CF) titer results in serial specimens are considered diagnostic of active disease.
Immunodiffusion:
The presence of IgM antibodies may be detectable within 2 weeks after the onset of symptoms; however, the antibody may be detected longer than 6 months after infection.
The presence of IgG antibodies parallels the CF antibodies and may suggest an active or a recent asymptomatic infection with Coccidioides immitis/posadasii; however, antibodies may persist after the infection has resolved.
An equivocal result (a band of nonidentity) cannot be interpreted as significant for a specific diagnosis. However, this may be an indication that a patient should be followed serologically.
Over 90% of primary symptomatic cases will be detected by combined immunodiffusion and CF testing.
- Interferences and Limitations
Cautions: Antibodies (both IgM and IgG) may be present after the infection has resolved.
- References
- Mayo Clinic Laboratories Clinical & Interpretive Information: Coccidioides Antibody, Complement Fixation and Immunodiffusion, Serum
- Washington State Department of Health Notifiable Conditions: Coccidioidomycosis (Valley Fever)
- Guidelines
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
6 mL blood in GOLD SST or RED TOP tube
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia.
- Quantity
-
requested: 1.8 mL serum
minimum: 1.2 mL serum
Processing
- Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: SCOC.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia.
Performance
- LIS Dept Code
- Sendouts Mayo Lab (RF) (MARF)
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-17103050 Superior Drive NW
Rochester, MN 55901 - Frequency
- Performed: Monday - Friday. Report Available: 4-7 days.
- Available STAT?
- No
Billing & Coding
- CPT codes
- 86635x3
- LOINC
- 87435-4
- Interfaced Order Code
- UOW4714