MOG Antibodies (Sendout)

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General Information

Lab Name
MOG Antibodies
Lab Code
RMOG
Epic Name
MOG Antibodies (Sendout)
External Test Id
MOGFS
Description

Useful For:

  • Diagnosis of inflammatory demyelinating diseases (IDD) with similar phenotype to neuromyelitis optica (NMO) spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis
  • Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy
  • Diagnosis of NMO
  • Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease
  • Diagnosis of ADEM
  • Prediction of a relapsing disease course

Testing Algorithm: When the results of this assay require further evaluation, the reflex titer test will be performed at an additional charge.

Patient Preparation: For optimal antibody detection, specimen collection should occur prior to initiation of immunosuppressant medication.

References
Synonyms
ADEM antibody, MOG IgG1, MOGFS, Myelin Oligodendrocyte Glycoprotein, NMO antibody, Optic Neuritis Antibody, Transverse Myelitis Antibody, Vision Loss Antibody
Components
Code Name
RMOGFS MOGAb, FACS

Interpretation

Method

Flow Cytometry

Reference Range
See individual components
Ref. Range Notes
Reference Value: Negative

Interpretation:

A positive value for myelin oligodendrocyte glycoprotein (MOG)-IgG is consistent with a neuromyelitis optica-like phenotype and, in the setting of acute disseminated encephalomyelitis, optic neuritis and transverse myelitis, indicates an autoimmune oligodendrogliopathy with potential for relapsing course. Identification of MOG-IgG allows distinction from multiple sclerosis (MS) and may justify initiation of appropriate immunosuppressive therapy (not MS disease-modifying agents) at the earliest possible time. This allows early initiation and maintenance of optimal therapy. Recommend follow-up in 6 to 12 months, as persistence of MOG-IgG seropositivity predicts a relapsing course.

This autoantibody is not found in healthy subjects.

Interferences and Limitations

Cautions: Myelin oligodendrocyte glycoprotein (MOG)-IgG, specifically MOG-IgG1, may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).

References

Ordering & Collection

Specimen Type
Blood
Collection

6 mL blood in a RED TOP tube or GOLD SST

Handling Instructions

Outside Laboratories: Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Quantity
Requested: 2 mL serum
Minimum: 1 mL Serum

Processing

Receiving Instructions

Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum.

Sendouts:

  • Order Mayo Test: MOGFS
  • Interfaced: Yes [Interface: 601; Worksheet: MARF]

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Misc Sendout

Performance

Lab Department
Sendouts Mayo Lab (RF)(MARF)
Frequency
Performed: Monday, Tuesday, Thursday. Reported: 5-8 days from sample receipt at Mayo Clinic Labs.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901

Billing & Coding

CPT Codes
86363
LOINC
18718-7
Interfaced Order Code
UOW3557