MOG Antibodies (Sendout)

Useful For:

• Diagnosis of inflammatory demyelinating diseases (IDD) with similar phenotype to neuromyelitis optica (NMO) spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis
• Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy
• Diagnosis of NMO
• Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease
• Diagnosis of ADEM
• Prediction of a relapsing disease course

Testing Algorithm: When the results of this assay require further evaluation, the reflex titer test will be performed at an additional charge.

Patient Preparation: For optimal antibody detection, specimen collection should occur prior to initiation of immunosuppressant medication.

Interpretation:

A positive value for myelin oligodendrocyte glycoprotein (MOG)-IgG is consistent with a neuromyelitis optica-like phenotype and, in the setting of acute disseminated encephalomyelitis, optic neuritis and transverse myelitis, indicates an autoimmune oligodendrogliopathy with potential for relapsing course. Identification of MOG-IgG allows distinction from multiple sclerosis (MS) and may justify initiation of appropriate immunosuppressive therapy (not MS disease-modifying agents) at the earliest possible time. This allows early initiation and maintenance of optimal therapy. Recommend follow-up in 6 to 12 months, as persistence of MOG-IgG seropositivity predicts a relapsing course.

A recent study evaluated which clinical, radiographic, and laboratory features best predict true-positive myelin oligodendrocyte glycoprotein (MOG) antibody results. The resulting TRUE-MOGAD score is a practical, weighted, point-based tool that helps distinguish MOG antibody-associated disease (MOGAD) among patients with positive MOG-IgG testing. It is particularly helpful in atypical or otherwise undifferentiated presentations and may support diagnostic and therapeutic decisions in clinical practice. However, it does not replace the 2023 MOGAD diagnostic criteria because it excludes key elements (eg, myelitis, brainstem/cerebellar syndromes, spinal fluid MOG-IgG); instead, it should be used as a complementary aid. To calculate your patient's TRUE MOGAD score, see the TRUE-MOGAD calculator.

This autoantibody is not found in healthy subjects.

Outside Laboratories: Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum.

Sendouts:

• Order Mayo Test: MOGFS
• Interfaced: Yes [Interface: 601; Worksheet: MARF]

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.