Hepatitis D Antibodies, Total (Sendout)
General Information
- Lab Name
- Hepatitis D Antibodies, Total
- Lab Code
- RHEPDA
- Epic Name
- Hepatitis D Antibodies, Total (Sendout)
- External Test Id
- AHDV
- Description
Useful for:
- Detection of hepatitis D virus (HDV)-specific total antibodies (combined IgG and IgM) in human serum
- Diagnosis of concurrent HDV infection in patients with fulminant acute hepatitis B virus (HBV) infection (acute coinfection), chronic HBV infection (chronic coinfection), or acute exacerbation of known chronic HBV infection (HDV superinfection)
- References
- Mayo Clinic Laboratories Clinical & Interpretive Information: Hepatitis D Virus Total Antibodies
- Synonyms
- AHDV, Anti-HDV, Delta Hepatitis, HDV Antibodies, Hepatitis Delta Antibodies
- Components
-
Code Name RHDAB Hepatitis D Ab (Total)
Interpretation
- Guidelines
- Method
Enzyme Immunoassay (EIA)
- Reference Range
- See individual components
- Ref. Range Notes
Reference Values: Negative
Interpretation:
This assay detects the presence of hepatitis D virus (HDV)-specific total (combined IgG and IgM) antibodies in serum.
Negative results indicate the absence of HDV infection and no past exposure to HDV.
Equivocal results indicate borderline level of anti-HDV total antibodies. Repeat testing in 1 to 2 weeks is recommended to determine the definitive HDV infection status.
Positive results usually indicate one of the following conditions: 1) simultaneous acute or chronic coinfection with hepatitis B virus (HBV) and HDV, 2) acute HDV infection in patients with known chronic HBV infection (ie, HDV superinfection), or 3) resolved HDV infection. Results should be correlated with medical history and clinical findings.
- Interferences and Limitations
Cautions:
Negative results may not rule-out hepatitis D virus (HDV) infection during the early phase of infection or in immunocompromised patients who have delayed or inadequate immune response.
False-positive results may be due to cross-reactive antibodies from other viral infection or underlying illnesses. Positive result should be correlated with the patient's clinical history, physical examination findings, and risk factors for HDV infection.
Performance characteristics have not been established for the following specimen characteristics:
- Grossly icteric (total bilirubin level of >20 mg/dL)
- Grossly lipemic (triolein level of >3000 mg/dL)
- Grossly hemolyzed (hemoglobin level of >500 mg/dL)
- Containing particulate matter
- Cadaveric specimens
- References
- Mayo Clinic Laboratories Clinical & Interpretive Information: Hepatitis D Virus Total Antibodies
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
Collect 3mL blood in RED TOP or GOLD SST tube
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Freeze serum at -20°C while awaiting shipment. Transport samples on dry ice.
Stability: Frozen (preferred): 30 days; Refrigerated: 30 days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
- Quantity
-
Requested: 1 mL serum
Minimum: 0.5 mL serum
Processing
- Receiving Instructions
Centrifuge and transfer serum to a separate plastic vial within 2 hours of collection. Freeze serum at -20°C.
Sendouts:
- Order Mayo Test: AHDV.
- Interfaced: Yes.
Stability: Frozen (preferred): 30 days; Refrigerated: 30 days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (FZ)(MAFZ)
- Frequency
- Performed: Varies. Maximum Laboratory Time: 7 days
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 86692
- LOINC
- 40727-0
- Interfaced Order Code
- UOW3967