Ganglioside Antibody Panel (Sendout)

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General Information

Lab Name
Ganglioside Antibody Panel (Sendout)
Lab Code
RGM1AG
Epic Name
Ganglioside Antibody Panel (Sendout)
External Test Id
GM1B, GAES
Description

Useful for: Supporting the diagnosis of an autoimmune neuropathy.

    Test Algorithm: This panel contains the following screening tests: GQ1b-IgG by ELISA, Monosialo GM1 IgG, Monosialo GM1 IgM, Disialo GD1b IgG, Disialo GD1b IgM. If positive, the corresponding titer will be performed at additional charge.

    Patient Preparation: For optimal antibody detection, specimen collection is recommended to occur prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.

      References
      Synonyms
      Disialo GD1b, GAES, GM-1, GM1, GM1 Antibody Panel, GM1B, GQ1b IgG Antibody, Monosialo GM1 Antibody
      Components
      Code Name
      RGANGI Ganglioside Antibody Interpretation
      RGQ1BG Ganglioside GQ1b IgG Antibody
      RDGD1G IgG Disialo GD1b
      RDGD1M IgM Disialo GD1b
      RMGM1G IgG Monosialo GM1
      RMGM1M IgM Monosialo GM1

      Interpretation

      Method

      Enzyme-Linked Immunosorbent Assay (ELISA)

      Reference Range
      See individual components
      Ref. Range Notes

      Reference Values:

      Panel Tests:

      GQ1b-IgG ELISA: Negative
      IgG Monosialo GM1: Negative
      IgM Monosialo GM1: Negative
      IgG Disialo GD1b: Negative
      IgM Disialo GD1b: Negative

      Reflex Tests:

      IgG Monosialo GM1 Titer: <1:2000
      IgM Monosialo GM1 Titer: <1:4000
      IgG Disialo GD1b Titer: <1:2000
      IgM Disialo GD1b Titer: <1:2000

      Interpretation: High titers (>1:8000) favor the diagnosis of multifocal motor neuropathy or multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy over motor neuron disease. About 30% to 50% of patients with these clinical syndromes or the pure motor variant of chronic inflammatory demyelinating polyneuropathy have ganglioside autoantibodies. High-antibody titers appear to be a specific, but not sensitive, marker of these related disorders.

      Interferences and Limitations

      Cautions: Positive titer values less than 1:16,000 may be found in motor neuron disease, monoclonal gammopathy of uncertain significance (MGUS), and healthy individuals. High titers are very specific of an autoimmune neuropathy.

      This test is not diagnostic and should be interpreted in the appropriate clinical context.

      This test does not include testing for GD1a autoantibodies.

      References

      Ordering & Collection

      Specimen Type
      Blood
      Collection

      Collect 3 mL blood in a RED TOP tube

      • Also Accepted: GOLD SST
      Handling Instructions

      Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate sample while awaiting shipment. Transport with a cold pack.

      Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

      Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

      Quantity
      Requested: 1 mL serum
      Minimum: 0.5 mL serum

      Processing

      Receiving Instructions

      Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

      Sendouts:

      • Order Mayo Test: GAES
      • Interfaced: Yes [Interface: 601; Worksheet: MARF]

      Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

      Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

      Misc Sendout

      Performance

      Lab Department
      Sendouts Mayo Lab (RF)(MARF)
      Frequency
      Performed: Monday, Wednesday, Friday. Report Available: 5-8 days from sample receipt at Mayo Clinic Labs.
      Available STAT?
      No
      Performing Location(s)
      Sendout Mayo Clinic Laboratories
      800-533-1710

      200 First Street Southwest
      Rochester, MN 55901

      Billing & Coding

      CPT Codes
      83516x5
      LOINC
      82455-7
      Interfaced Order Code
      UOW4160