Ganglioside Antibody Panel (Sendout)
General Information
- Lab Name
- Ganglioside Antibody Panel (Sendout)
- Lab Code
- RGM1AG
- Epic Name
- Ganglioside Antibody Panel (Sendout)
- External Test Id
- GM1B, GAES
- Description
Useful for: Supporting the diagnosis of an autoimmune neuropathy.
Test Algorithm: This panel contains the following screening tests: GQ1b-IgG by ELISA, Monosialo GM1 IgG, Monosialo GM1 IgM, Disialo GD1b IgG, Disialo GD1b IgM. If positive, the corresponding titer will be performed at additional charge.
Patient Preparation: For optimal antibody detection, specimen collection is recommended to occur prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
- References
- Mayo Clinical & Interpretive Information: Ganglioside Antibody Panel, Serum
- Synonyms
- Disialo GD1b, GAES, GM-1, GM1, GM1 Antibody Panel, GM1B, GQ1b IgG Antibody, Monosialo GM1 Antibody
- Components
-
Code Name RGANGI Ganglioside Antibody Interpretation RGQ1BG Ganglioside GQ1b IgG Antibody RDGD1G IgG Disialo GD1b RDGD1M IgM Disialo GD1b RMGM1G IgG Monosialo GM1 RMGM1M IgM Monosialo GM1
Interpretation
- Method
Enzyme-Linked Immunosorbent Assay (ELISA)
- Reference Range
- See individual components
- Ref. Range Notes
Reference Values:
Panel Tests:
GQ1b-IgG ELISA: Negative IgG Monosialo GM1: Negative IgM Monosialo GM1: Negative IgG Disialo GD1b: Negative IgM Disialo GD1b: Negative Reflex Tests:
IgG Monosialo GM1 Titer: <1:2000 IgM Monosialo GM1 Titer: <1:4000 IgG Disialo GD1b Titer: <1:2000 IgM Disialo GD1b Titer: <1:2000 Interpretation: High titers (>1:8000) favor the diagnosis of multifocal motor neuropathy or multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy over motor neuron disease. About 30% to 50% of patients with these clinical syndromes or the pure motor variant of chronic inflammatory demyelinating polyneuropathy have ganglioside autoantibodies. High-antibody titers appear to be a specific, but not sensitive, marker of these related disorders.
- Interferences and Limitations
Cautions: Positive titer values less than 1:16,000 may be found in motor neuron disease, monoclonal gammopathy of uncertain significance (MGUS), and healthy individuals. High titers are very specific of an autoimmune neuropathy.
This test is not diagnostic and should be interpreted in the appropriate clinical context.
This test does not include testing for GD1a autoantibodies.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
Collect 3 mL blood in a RED TOP tube
- Also Accepted: GOLD SST
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate sample while awaiting shipment. Transport with a cold pack.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
- Quantity
-
Requested: 1 mL serum
Minimum: 0.5 mL serum
Processing
- Receiving Instructions
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: GAES
- Interfaced: Yes [Interface: 601; Worksheet: MARF]
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (RF)(MARF)
- Frequency
- Performed: Monday, Wednesday, Friday. Report Available: 5-8 days from sample receipt at Mayo Clinic Labs.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 83516x5
- LOINC
- 82455-7
- Interfaced Order Code
- UOW4160