Estrone (Sendout)

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General Information

Lab Name
Estrone (E1)
Lab Code
RESTRN
Epic Name
Estrone, Serum (Sendout)
External Test Id
E1
Description

Useful For:

  • As part of the diagnosis and workup of precocious and delayed puberty in females and, to a lesser degree, males
  • As part of the diagnosis and workup of suspected disorders of sex steroid metabolism (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)
  • As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
  • Monitoring low-dose female hormone replacement therapy in postmenopausal women
  • Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)
References
  1. Mayo Clinical & Interpretive Information: Estrone, Serum
  2. Mayo Steroid Pathways Algorithm
Synonyms
E1
Components

Interpretation

Method

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reference Range
Units: pg/mL
Ref. Range Notes

Children:

1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days. The reference ranges for children are based on the published literature¹, cross-correlation of Mayo's assay with assays used to generate the literature data and on Mayo data for young adults.

Males:

Tanner Stages: Mean Age: Reference Range:
Stage I (>14 days and prepubertal) 7.1 years Undetectable-16 pg/mL
Stage II 11.5 years Undetectable-22 pg/mL
Stage III 13.6 years 10-25 pg/mL
Stage IV 15.1 years 10-46 pg/mL
Stage V 18 years 10-60 pg/mL

Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

Females:

Tanner Stages: Mean Age: Reference Range:
Stage I (>14 days and prepubertal) 7.1 years Undetectable-29 pg/mL
Stage II 10.5 years 10-33 pg/mL
Stage III 11.6 years 15-43 pg/mL
Stage IV 12.3 years 16-77 pg/mL
StageV 14.5 years 17-200 pg/mL

Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

Adults:

Sex Reference Range
Males: 10-60 pg/mL
Females, Premenopausal: 17-200 pg/mL
Females, Premenopausal: 7-40 pg/mL

Conversion factor: E1: pg/mL x 3.704=pmol/L (molecular weight=270)

References
  1. Mayo Clinical & Interpretive Information: Estrone, Serum
  2. Mayo Steroid Pathways Algorithm

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in a RED TOP tube

Unacceptable: SST/Gel Separator tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum while awaiting shipment. Transport with a cold pack.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 28 days.

Reject Due To: Serum from SST/gel tube. Gross hemolysis, lipemia, or icterus samples are acceptable.

Quantity
Requested: 1.2 mL serum
Minimum: 0.8 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum.

Sendouts:

  • Order Mayo Test: E1
  • Interfaced: Yes [Interface: 601; Worksheet: MARF]

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 28 days.

Reject Due To: Serum from SST/gel tube. Gross hemolysis, lipemia, or icterus samples are acceptable.

Misc Sendout

Performance

Lab Department
Sendouts Mayo Lab (RF)(MARF)
Frequency
Performed: Monday through Saturday. Reported: 2-6 days from sample receipt at Mayo Clinic Laboratories.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901

Billing & Coding

CPT Codes
82679
LOINC
2258-2
Interfaced Order Code
UOW1974
Interfaced Result Code
UOW1974