Estrone (Sendout)
General Information
- Lab Name
- Estrone (E1)
- Lab Code
- RESTRN
- Epic Name
- Estrone, Serum (Sendout)
- External Test Id
- E1
- Description
Useful For:
- As part of the diagnosis and workup of precocious and delayed puberty in females and, to a lesser degree, males
- As part of the diagnosis and workup of suspected disorders of sex steroid metabolism (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)
- As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
- Monitoring low-dose female hormone replacement therapy in postmenopausal women
- Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)
- References
- Mayo Clinical & Interpretive Information: Estrone, Serum
- Mayo Steroid Pathways Algorithm
- Synonyms
- E1
- Components
Interpretation
- Method
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- Reference Range
- Units: pg/mL
- Ref. Range Notes
Children:
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days. The reference ranges for children are based on the published literature¹, cross-correlation of Mayo's assay with assays used to generate the literature data and on Mayo data for young adults.
Males:
Tanner Stages: Mean Age: Reference Range: Stage I (>14 days and prepubertal) 7.1 years Undetectable-16 pg/mL Stage II 11.5 years Undetectable-22 pg/mL Stage III 13.6 years 10-25 pg/mL Stage IV 15.1 years 10-46 pg/mL Stage V 18 years 10-60 pg/mL Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females:
Tanner Stages: Mean Age: Reference Range: Stage I (>14 days and prepubertal) 7.1 years Undetectable-29 pg/mL Stage II 10.5 years 10-33 pg/mL Stage III 11.6 years 15-43 pg/mL Stage IV 12.3 years 16-77 pg/mL StageV 14.5 years 17-200 pg/mL Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Adults:
Sex Reference Range Males: 10-60 pg/mL Females, Premenopausal: 17-200 pg/mL Females, Premenopausal: 7-40 pg/mL Conversion factor: E1: pg/mL x 3.704=pmol/L (molecular weight=270)
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
3 mL blood in a RED TOP tube
Unacceptable: SST/Gel Separator tube
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum while awaiting shipment. Transport with a cold pack.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 28 days.
Reject Due To: Serum from SST/gel tube. Gross hemolysis, lipemia, or icterus samples are acceptable.
- Quantity
-
Requested: 1.2 mL serum
Minimum: 0.8 mL serum
Processing
- Receiving Instructions
Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum.
Sendouts:
- Order Mayo Test: E1
- Interfaced: Yes [Interface: 601; Worksheet: MARF]
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 28 days.
Reject Due To: Serum from SST/gel tube. Gross hemolysis, lipemia, or icterus samples are acceptable.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (RF)(MARF)
- Frequency
- Performed: Monday through Saturday. Reported: 2-6 days from sample receipt at Mayo Clinic Laboratories.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-17103050 Superior Drive NW
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 82679
- LOINC
- 2258-2
- Interfaced Order Code
- UOW1974
- Interfaced Result Code
- UOW1974