Coccidioides Antibodies, CSF (Sendout)
General Information
- Lab Name
- Coccidioides Antibodies, CSF (Sendout)
- Lab Code
- RCCOCC
- Epic Name
- Coccidioides Antibodies, CSF (Sendout)
- External Test Id
- CCOC
- Description
Useful For: Diagnosing coccidioidomycosis using spinal fluid specimens.
- References
- Mayo Clinical & Interpretive Information: Coccidioides Antibody, Complement Fixation and Immunodiffusion, Spinal Fluid
- Washington State Department of Health Notifiable Conditions: Coccidioidomycosis (Valley Fever)
- Synonyms
- CCOC, Coccidioides Spinal Fluid, San Joaquin Valley Fever CSF, Valley Fever CSF
- Components
Interpretation
- Guidelines
- Method
Complement Fixation (CF), Immunodiffusion (ID)
- Reference Range
- See individual components
- Ref. Range Notes
Interpretation:
- Complement Fixation: IgG antibody is detected by complement fixation (CF) testing. Any CF titer in cerebrospinal fluid (CSF) should be considered significant. A positive complement fixation test in un-concentrated CSF is diagnostic of meningitis.
- Immunodiffusion: IgM and IgG precipitins are rarely found in CSF. However, when present, they are diagnostic of meningitis (100% specific). Since the immunodiffusion test is 100% specific, it is helpful in interpreting CF results.
- Interferences and Limitations
Cautions: While complement fixation (CF) titers may be present in serum months after the infection has resolved, any CF titer in spinal fluid should be considered significant.
- References
- Mayo Clinical & Interpretive Information: Coccidioides Antibody, Complement Fixation and Immunodiffusion, Spinal Fluid
- Washington State Department of Health Notifiable Conditions: Coccidioidomycosis (Valley Fever)
Ordering & Collection
- Specimen Type
- CSF
- Collection
-
Collect 2 mL CSF in a sterile container.
- Handling Instructions
Outside Laboratories: Submit 2 mL refrigerated CSF in a sterile vial.
Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.
- Quantity
-
Requested: 2 mL CSF
Minimum: 1.2 mL CSF
Processing
- Receiving Instructions
Refrigerate CSF in a sterile vial.
Sendouts:
- Order Mayo Test: CCOC.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (RF)(MARF)
- Frequency
- Performed: Monday- Friday. Report Available: 3-6 days.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-17103050 Superior Drive NW
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 86635x3
- LOINC
- 88745-5
- Interfaced Order Code
- UOW4710