BCR/ABL p210, Quant by RT PCR

General Information

Lab Name

BCR/ABL p210, Quant by RT PCR

Lab Code

QP210

Epic Name

BCR/ABL p210 Quantitative

Description

This assay is a nucleic acid amplification test for the quantitation of BCR::ABL1 p210 transcripts (e13a2 and e14a2) in total RNA from whole blood or bone marrow aspirate. This quantitative test is recommended for therapeutic monitoring and detection of minimal residual disease for patients with an established diagnosis. The test does not differentiate between e13a2/b2a2 or e14a2/b3a2 fusion transcripts and does not detect other rare fusion transcripts resulting from t(9;22).

To facilitate the interlaboratory comparison of findings and the assessment of molecular milestones (major molecular response or MMR), results are reported using the International Scale.

For the p190 fusion form (minor breakpoint), order BCR/ABL p190, Quant by RT PCR [QP190]

For patients with uncertain diagnosis or unknown forms of BCR::ABL1 fusion transcripts, please consider ordering BCR/ABL p210, Quant Reflexive [QP210R]
The reportable range is 0.0030% to 50% IS

The limit of detection is 0.0030% IS.

Stability is 72 hrs. Specimens received after 72 hrs. will be rejected.

Limitations: This assay in unable to detect BCR::ABL1 p190, p230, or other rare transcripts.

Please complete the appropriate request form based on your patient location. Hematopathology test request form can be found at Clinical Pathology Test Order Forms.

Forms & Requisitions

Requisition

Synonyms

ALL, B-ALL, B-Cell Acute Lymphoblastic Leukemia, BALL, BCR::ABL1, Chronic Myelogenous Leukemia, CML, p210, P210, Philadelphia chromosome Ph major, QP210, Quantitative BCR/ABL p210, Quantitative RT-PCR, t(9;22)

Components

Code	Name
P210SD	BCR/ABL p210 Specimen Desc
P210RS	BCR/ABL p210 Result
P210IS	BCR/ABL p210 %IS
P210IN	BCR/ABL p210 Interpretation
P210M	BCR/ABL p210 Method
P210GR	P210 Case Number