Inflammatory Bowel Disease Serology Panel

General Information

Lab Name

Lab Code

546

External Test Id

IBDP2

Description

Useful For:

Distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and imaging evaluations.
This test is not useful for determining the extent of disease in patients with inflammatory bowel disease or determining the response to disease-specific therapy including surgical resection of diseased intestine.

This panel includes Saccharomyces cerevisiae IgA antibody, Saccharomyces cerevisiae IgG antibody, and Cytoplasmic Neutrophilic Antibody.

For orders specifying "IBD sgi panel" or "Prometheus IBD sgi Diagnostic Panel," refer to separate test guide #548.

Synonyms

Anti Saccharomyces, ASCA, Cerevisiae, Crohn, Crohns Disease, IBD serology, IBDP2, Inflammatory Bowel Disease, Ulcerative Colitis

Components

Method: ASCA: Enzyme-Linked Immunosorbent Assay (ELISA)

p-ANCA: Indirect Immunofluorescent Assay (IFA)
Reference Range
Interferences and Limitations: Cautions:

Results from this test should not be exclusively relied upon to establish the diagnosis of ulcerative colitis (UC) or Crohn disease (CD) or to distinguish between these 2 diseases.

Some patients with CD have detectable antineutrophil cytoplasmic antibodies (ANCA), and some patients with UC have detectable IgA and/or IgG anti-Saccharomyces cerevisiae antibodies (ASCA).

ANCA results may be reported as indeterminate if interfering antinuclear antibodies (ANA) are present.

Specimen Type: Blood
Collection: 6 mL blood in GOLD SST or RED TOP tube
Handling Instructions: Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, or heat-inactivated specimen. Gross icterus okay.
Quantity: Requested: 1 mL serum
Minimum: 0.8 mL serum

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Login: SEND1-;REFRIG

Sendouts, order Mayo Test: IBDP2.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, or heat-inactivated specimen. Gross icterus okay.

Lab Department

Frequency

Performed: Varies. Reported: 1 day.

Available STAT?

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901