Histamine, Plasma (Sendout)

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General Information

Lab Name
Lab Code
165
External Test Id
0070036
Description

Ordering Recommendation: Aids in evaluation of patient with allergic signs and symptoms, such as anaphylaxis; may assist in diagnosing and monitoring of mast-cell activation disorders.

For evaluating patients for diseases of immediate hypersensitivity, the preferred screening test is Tryptase [TRYPT]. Test results are highly dependent on proper sample collection. Histamine may be released ex vivo by passing basophils in blood through a small-bore needle under vacuum or when blood clots. Serum should not be used in order to avoid the artifactual release of histamine from basophils that can occur during clotting.

Ordering Requirements: This test requires approval by the Lab Medicine Resident (LMR) on-call. Contact the resident via the paging operator at (206) 598-6190.

Synonyms
0070036, Anaphylaxis, Immediate hypersensitivity
Components

Interpretation

Method

Quantitative Enzyme-Linked Immunosorbent Assay

Reference Range
Ref. Range Notes
Reference Interval: 0-8 nmol/L

Ordering & Collection

Specimen Type
plasma
Collection

Collect 3 mL blood in a pre-chilled Lavender (EDTA) top tube. After collection, place sample immediately on wet ice and expedite transport to the lab.

Approval Required
Laboratory Medicine Resident (LMR) approval is required.
Handling Instructions

Outside Laboratories: Centrifuge sample in a refrigerated centrifuge (2-8°C) and separate the upper two-thirds of plasma within 20 minutes. Transfer 1 mL plasma to a separate plastic vial and freeze immediately at -20°C. Transport on dry ice.

Stability: After separation from cells: Frozen (Critical): 6 months; Refrigerated: 6 hours; Ambient: Unacceptable.

Unacceptable Conditions: Nonfrozen or hemolyzed specimens.

Quantity
Requested: 1 mL plasma
Minimum: 0.5 mL plasma

Processing

Receiving Instructions

Centrifuge sample in a refrigerated centrifuge (2-8°C) and separate the upper two-thirds of plasma within 20 minutes. Transfer 1 mL plasma to a separate plastic vial and freeze immediately at -20°C.

Sendouts:

  • Order ARUP Test: 0070036
  • Interfaced: Yes [Interface: 602; Department: ARPZ]

Stability: After separation from cells: Frozen (Critical): 6 months; Refrigerated: 6 hours; Ambient: Unacceptable.

Unacceptable Conditions: Nonfrozen or hemolyzed specimens.

Misc Sendout

Performance

Lab Department
Frequency
Performed: Tuesday, Saturday. Reported: 1-6 days from sample receipt at ARUP Laboratories.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

Billing Comments

CPT: 83088