Histamine, Urine (Sendout)

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General Information

Lab Name
Lab Code
164
External Test Id
0070038
Description

Ordering Recommendation: Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis. May assist when diagnosing and monitoring mast-cell activation disorders or when evaluating histamine production over a longer time frame.

For evaluating patients for diseases of immediate hypersensitivity or mast cell proliferation (mastocytosis), the preferred screening test is Tryptase [TRYPT]. Test results are highly dependent on appropriate sample collection.

Ordering Requirements: This test requires approval by the Lab Medicine Resident (LMR) on-call. Contact the resident via the paging operator at (206) 598-6190.

References
Synonyms
0070038, Mast Cell Disease, Mastocytosis, Systemic Mastocytosis
Components

Interpretation

Method

Quantitative Enzyme Immunoassay

Reference Range
Ref. Range Notes

Referance Intervals:

Histamine, Urine - ratio to CRT: 0-450 nmol/g crt
Histamine, Urine, Excretion - 24h: 0-60 µg/day
References

Ordering & Collection

Specimen Type
Urine
Collection

Random or 24-hour urine collection in a preservative-free container.

  • Timed collections should be refrigerated during collection and expedited to the lab after completion. Urine must be aliquoted and frozen within 6 hours after collection is complete.
Handling Instructions

Outside Laboratories:

  • For timed collections, mix specimen well. Measure and record total volume. Document the collection interval and total volume on the requisition.
  • Transfer 4 mL urine (min 1 mL) to a separate, screw-top plastic vial, leaving room at the top for expansion.
  • Freeze urine aliquot immediately at -20°C. Transport on dry ice.

Stability: Frozen (Critical): 6 months; Refrigerated: 6 hours*; Ambient: Unacceptable.

  • *Note: For timed specimens, refrigerate during collection. Sample is stable for 6 hours after the collection is complete.
Quantity
Requested: 4.5 mL urine
Minimum: 1 mL urine

Processing

Receiving Instructions
  • For timed collections, mix specimen well. Measure and record total volume. Document the collection interval and total volume on the requisition.
  • Transfer 4 mL urine (min 1 mL) to a separate, screw-top plastic vial, leaving room at the top for expansion. Freeze urine aliquot immediately at -20°C.

Sendouts:

  • Order ARUP Test: 0070038
  • Interfaced: Yes [Interface: 602; Department: ARPZ]

Stability: Frozen (Critical): 6 months; Refrigerated: 6 hours*; Ambient: Unacceptable.

  • *Note: For timed specimens, refrigerate during collection. Sample is stable for 6 hours after the collection is complete.
Misc Sendout

Performance

Lab Department
Frequency
Performed: Tuesday, Saturday. Reported: 1-6 days from sample receipt at ARUP Laboratories.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

Billing Comments

CPT: 83088; LOINC: 9410-2