Tryptase (Sendout)

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General Information

Lab Name
Lab Code
1181
External Test Id
TRYPT
Description

Useful For:

  • Evaluation of individuals with suspected mast cell activation, which may occur as a result of anaphylaxis or allergen challenge
  • Evaluation of patients with suspected mast cell activation syndrome
  • Evaluation of patients with suspected cutaneous or systemic mastocytosis
References
Synonyms
Mast Cell Tryptase, TRYPT
Components

Interpretation

Method

Fluorescence Enzyme Immunoassay (FEIA)

Reference Range
Ref. Range Notes
Reference Value: <11.5 ng/mL
Interferences and Limitations

Cautions: The most prevalent cause of elevated basal serum tryptase has been associated with hereditary alpha-tryptasemia, a common autosomal dominant trait unaccompanied by mast cell related symptoms in most individuals.

Normal tryptase concentrations may be observed in some patients with acute mast cell activation if specimens are obtained greater than 12 hours after an anaphylactic episode or allergen challenge.

Some individuals may demonstrate an increase in tryptase concentrations above baseline after anaphylaxis or allergen challenge while remaining below 11.5 ng/mL; measurement of tryptase in specimens obtained 1 to 6 hours and at least 24 hours after the episode may be useful in demonstrating a transient increase in concentrations.

References

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in GOLD SST or RED TOP tube

Handling Instructions

Outside Laboratories: Centrifuge sample and aliquot serum into a separate plastic vial. Freeze serum at -20°C while awaiting shipment. Transport on dry ice.

Interface Clients: This test is not available for direct ordering in interface systems. Orders must be placed using a paper requisition. Results will not file via interface.

Stability: Frozen (preferred): 14 days; Refrigerated: 7 days; Ambient: Unacceptable.

Quantity
Requested: 0.5 mL serum
Minimum: 0.2 mL serum

Processing

Receiving Instructions

Centrifuge sample and aliquot serum into a separate plastic vial. Freeze serum at -20°C.

Login: SEND1-;FREEZE SERUM

  • RSNDT1: MAYOSD
  • RSTYP1: SRM
  • RTSRQ1: ;Tryptase, Serum (Mayo Test TRYPT)

Order Notes:

  • Orders for Tryptase [TRYPT] received during the downtime may be changed to the Mayo test (SEND1) without provider notification.
  • Interface clients will not be able to order SEND1 directly. Clients should submit orders using a paper requisition. If TRYPT orders are received from interface clients, they must be re-logged manually using the appropriate non-interfaced client code.

Sendouts:

  • Order Mayo Test: TRYPT

Stability: Frozen (preferred): 14 days; Refrigerated: 7 days; Ambient: Unacceptable.

Misc Sendout

Performance

Lab Department
Frequency
Performed: Monday through Friday. Reported: 2-5 days from sample receipt at Mayo Clinic Labs.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901

Billing & Coding

Billing Comments

CPT: 83520