Cryofibrinogen Package
General Information
- Lab Name
- Cryofibrinogen
- Lab Code
- CRYOFB
- Epic Name
- Cryofibrinogen
- Description
Cryofibrinogenemia refers to the presence of cold-precipitating proteins in plasma but not in serum, with results reported at 3 and 10 days. A semi-quantitative estimate of the amount of precipitate is reported when present. If a cryofibrinogen precipitate is present in both blue citrate and green heparin plasma tubes but not in serum, it is more likely to be clinically significant. Presence of cryofibrinogens in the peripheral blood can be asymptomatic, but is associated with a variety of conditions including malignancy, infection, systemic rheumatic diseases or thromboembolic disorders.
- Components
-
Code Name CRFBLU Cryofibrinogen_Citrate CRFB Cryofibrinogen,Citrate 3 day CRFB10 Cryofibrinogen,Citrate 10 day CRFBLM Cryofibrinogen,Citrate Method CRFGRN Cryofibrinogen_Heparin CRFG Cryofibrinogen,Heparin 3 day CRFG10 Cryofibrinogen,Heparin 10 day CRFGRM Cryofibrinogen,Heparin Method CRFRED Cryoglobulin_Serum CRYO Cryoglobulin, Serum at 3 day CRYO10 Cryoglobulin, Serum at 10 day CRYFRM Cryoglobulin,Serum Method XCRFB2 CRYBLU, xtra tube (2nd) XCRFB3 CRYBLU, xtra tube (3rd) XCRFB4 CRYBLU, xtra tube (4th) XCRFGN CRYGRN, xtra tube XCRFRD CRYRED, xtra tube
Interpretation
- Method
Precipitation (Passive precipitation at refrigerator temperature, that is reversible when warmed to 37°C)
- Reference Range
- See individual components
- Interferences and Limitations
False negative results if samples are not kept at 37°C between collection and cell separation step.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
15 mL blood in each tube type, RED + BLUE + GREEN TOP. Specimens must be maintained at 37°C after collection.
- Handling Instructions
Keep ALL tubes warm and transport to lab IMMEDIATELY. Suggest transporting specimens maintained at 37°C, possibly under your arm with specimen tubes securely enclosed in a specimen transport bag. Specimens will be rejected if clotted. This test is NOT drawn on Blood draw rounds.
- Quantity
-
Requested: 5 mL serum/plasma from each tube type
Minimum: 3 mL serum/plasma from each tube type
Processing
- Receiving Instructions
UW-MT Instructions
Specimen MUST be kept at 37°C until received by COAG Lab. COAG: Put "unclotted" specimen in 37°C waterbath to clot for 1-2 hours to prevent CRYOGLOBULINS from being trapped in clot. After clotting is complete, spin & aliquot serum while serum is still warm. Return sample to the refrigerator in SPS. Do Not Freeze.
HMC Instructions
Specimen MUST be kept at 37°C until received by SPS. SPS will put "unclotted" specimen in 37°C waterbath to clot for 1-2 hours to prevent CRYOGLOBULINS from being trapped in clot. After clotting is complete, spin & aliquot serum while serum is still warm. Refrigerate serum. Do not freeze.
Outside Lab Instructions
Specimens MUST be kept at 37°C until received in the lab. The lab will put "unclotted" specimens in 37°C waterbath to clot for 1-2 hours to prevent CRYOGLOBULINS from being trapped in clot. The Blue and Green Top tubes should stay in the waterbath until the RED Top tube has clotted. If a waterbath is not available, a 37°C heat block is acceptable. After clotting is complete, spin & aliquot serum while serum is still warm. Refrigerate serum. Do not freeze.
- Misc Sendout
Performance
- Lab Department
- Frequency
- Monday-Friday, results in 10 days
- Available STAT?
- No
- Performing Location(s)
-
UW-MT Immunology
206-520-4600Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195
Billing & Coding
- CPT Codes
- 82585x2, 82595
- LOINC
- 74352-6
- Interfaced Order Code
- UOW1577