VerifyNow Platelet Inhibition

General Information

Lab Name

VerifyNow Platelet Inhibition

Lab Code

VERPLT

Epic Name

VerifyNow Platelet Inhibition

Description

Results could be affected by the following: GPIIb/IIIa inhibitors, low HCT, low PLT or inherited platelet disorders. Patients with HCT<20% or PLT<50 K/uL cannot be tested with the VerifyNow Assay. Samples should be collected 2 to 30 hours after ingestion of aspirin to show drug effect. Suggested timing for testing patients on P2Y12 inhibitory drugs is dependent on dosage given.

VerifyNow P2Y12 Suggested Sample Draw Time:

Medications Tested	Dose Given	Suggested Sample Draw Time
Clopidogrel (Plavix)	75 mg	7 days on maintenance
Clopidogrel (Plavix)	300 mg	8 hours post bolus
Clopidogrel (Plavix)	600 mg	6 hours post bolus
Prasugrel (Effient)	5 mg	5 days on maintenance
Prasugrel (Effient)	10 mg	5 days on maintenance
Prasugrel (Effient)	60 mg	45 minutes post bolus
Ticagrelor (Brilinta)	90 mg (bid)	1 day on maintenance (within 8 hours of last dose for maximal effect)
Ticagrelor (Brilinta)	180 mg	2 hours post bolus (within 8 hours for maximal effect)

Do not test patients who have taken a GP llb/llla inhibitor tirofiban (Aggrastat®) or eptifibatide (Integrilin®) within two days, or abciximab (ReoPro®) within two weeks. Depending on the amount of GP IIb/IIIa inhibitor present in the sample, P2Y12 results may be markedly shortened or Error/Attention code may be displayed.

Synonyms

ASA resistance, aspirin resistance, clopidogrel, Effient, Efient, Plavix, Prasugrel, Ticlid, ticolpidine, Verify Now, VerifyNow PRU

Components

Code	Name
VERASG	VerifyNow Aspirin Assay Group
VERASP	VerifyNow Aspirin Assay
VERP2Y	VerifyNow P2Y12 Assay
P2Y12	VerifyNow P2Y12 Reaction