Chromosome Analysis, FHCC

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General Information

Lab Name
Chromosome Analysis, FHCC
Lab Code
SCHRAN
Epic Name
Chromosome Analysis, FHCC
Description

Test Information: Placeholder test for samples sent to Fred Hutch Clinical Cancer Genomics Laboratory (formerly FHCC Cytogenetics Lab). Karyotype analysis includes complete chromosome analysis of at least twenty metaphases with at least two cut karyotypes. The presence or absence of an acquired clonal chromosomal abnormality may aid in defining diagnosis and prognosis, treatment response, and relapse, or evaluate for secondary hematologic malignancy. Chromosome analysis on potential donors may also be requested to rule out a genetic clonal process.

    Ordering Note: FHCC Clinical Cancer Genomics Laboratory (formerly FHCC Cytogenetics) is unable to accept orders collected at Fred Hutch NW Clinic (SNGEN). Samples collected at this location should be forwarded to UW Cytogenetics and Genomics Laboratory with a copy of the Epic requisition. Questions about sample acceptability may be referred to Fred Hutch Cytogenetics at (206) 606-1390.

    Synonyms
    Conventional Cytogenetics, Karyotyping, SCHRAN
    Components
    Code Name
    SPCHRM Collection Status, Chromosome
    CSCHRM Collected Specimen, Chromosome

    Interpretation

    Method

    Cell culturing and karyotyping

    Reference Range
    See individual components
    Interferences and Limitations

    The Clinical Cancer Genomics Laboratory does not perform fragility testing for Fanconi Anemia (also known as a breakage study). This test will be sent out by UW Medicine as a reference test. See Chromosome Breakage Analysis (Sendout) [RFACBA].

    Ordering & Collection

    Specimen Type
    Bone Marrow, Bone Biopsy Core, Leukemic Peripheral Blood, Lymph Node
    Collection

    Bone Marrow: 1-2 mL bone marrow in GREEN TOP (Sodium Heparin) tube

    Peripheral Blood: 5 mL blood GREEN TOP (Sodium Heparin) tube

    All Other Sample Types: Consult the FHCC Cancer Genomics Lab prior to collection by calling (206) 606-1390.

    Quantity
    Requested: Bone Marrow 1-2 mL; Peripheral Blood 5 mL
    Minimum: Bone Marrow 1 mL; Peripheral Blood: 1-2 mL

    Processing

    Receiving Instructions

    Bone Marrow or Blood: Store and transport specimens at ambient temperature.

    • Transport sample(s) to FHCC Clinical Cancer Genomics Laboratory immediately with a copy of the Epic requisition.
    • Do not hold specimens over the weekend/holiday. Contact the Cytogenetics Lab on-call via pager at (206) 340-7207.

    Note: FHCC Clinical Cancer Genomics Laboratory (formerly FHCC Cytogenetics) is unable to accept orders collected at Fred Hutch Northwest Clinic (SNGEN). Samples collected at this location should be forwarded to UW Cytogenetics and Genomics Laboratory with a copy of the Epic requisition. Questions about sample acceptability may be referred to Fred Hutch Cytogenetics at (206) 606-1390.

    Misc Sendout

    Performance

    Lab Department
    FHCC Lab - Misc(SAM)
    Frequency
    Performed: Monday through Friday, 8 am – 5 pm. Turnaround Time: 1 week. Weekends/holidays on-call pager: 206.340.7207
    Available STAT?
    Yes, by arrangement. Contact (206) 606-1390.
    Performing Location(s)
    FHCC FHCC Clinical Cancer Genomics Laboratory (formerly FHCC Cytogenetics)
    206-606-1390

    188 E. Blaine St.
    Suite 250, Room 2123
    Seattle, WA 98102

    Fax: 206-606-1399
    Email: cytolab@fredhutch.org
    Weekends/Holidays/After-hours Pager: (206) 340-7207

    Billing & Coding

    Interfaced Order Code
    UOW5666
    Billing Comments

    CPTs: 88237 or 88230; 88264 or 88262