Zika Virus Antibody, IgM (Sendout)
General Information
- Lab Name
- Zika Virus Antibody, IgM (Sendout)
- Lab Code
- RZIKM
- Epic Name
- Zika Virus Antibody, IgM (Sendout)
- External Test Id
- VZIKM
- Description
Useful For: Screening for presence of IgM-class antibodies to Zika virus. This assay should be used in patients presenting at least 2 weeks post-symptom onset or last possible exposure to Zika virus. Reverse transcription-polymerase chain reaction (RT-PCR) for Zika virus RNA detection should be ordered in patients with less than 2 weeks of symptoms or postexposure. For Zika Virus RT-PCR, refer to separate test guide #991.
- This test is not intended for medical-legal use.
- This test is not recommended for asymptomatic couples attempting conception.
Testing Algorithm:
- Mayo Clinic Laboratories: Assessment for Zika Virus Infection
- Components
-
Code Name RZIKMR Zika Virus IgM Ab Result
Interpretation
- Guidelines
- Method
IgM Antibody Capture Enzyme-Linked Immunosorbent Assay (MAC-ELISA)
- Reference Range
- See individual components
- Ref. Range Notes
Interpretation:
Presumptive Zika Positive: IgM-class antibodies to Zika virus (ZIKV) detected. This is a preliminary result and does not confirm evidence of ZIKV infection. Confirmatory testing may be required as determined by your local health department. False-positive results may occur in patients with other current or prior flavivirus infections (eg, dengue virus). For patients with less than 7 days of symptoms or last possible exposure to ZIKV, reverse transcription-polymerase chain reaction (RT-PCR) for ZIKV on serum and urine is recommended. A positive ZIKV RT-PCR result on either specimen is confirmatory for ZIKV infection.
Other Flavivirus Positive: Antibodies to a flavivirus, not ZIKV, were detected. Consider targeted testing for IgM-class antibodies to dengue and/or West Nile viruses as appropriate, taking into consideration patient exposure and presentation.
Negative: No evidence of IgM-class antibodies to ZIKV. For specimens collected less than 7 days post symptom onset or possible ZIKV exposure, RT-PCR for ZIKV on serum and urine to exclude a false-negative ZIKV IgM result is recommended. For symptomatic patients with travel to dengue endemic areas, testing for IgM antibodies to dengue virus is also recommended.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
8 mL blood in RED TOP tube or GOLD SST
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Freeze serum at -20°C.
Stability: Frozen (required): 30 days; Refrigerated: Unacceptable; Ambient: Unacceptable.
Reject Due to: Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen.
- Quantity
-
Requested: 2.5 mL serum
Minimum: 2 mL serum
Processing
- Receiving Instructions
Centrifuge sample and transfer serum to a separate plastic vial. Freeze serum at -20°C.
Sendouts:
- Order Mayo Test: VZIKM.
- Interfaced: Yes.
Stability: Frozen (required): 30 days; Refrigerated: Unacceptable; Ambient: Unacceptable.
Reject Due to: Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (FZ)(MAFZ)
- Frequency
- Performed: Bimonthly on the first and third Wednesday. Report Available: 1-14 days.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-17103050 Superior Drive NW
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 86794
- LOINC
- 80824-6
- Interfaced Order Code
- UOW5221