Topiramate (Sendout)

Interpretation

Method

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reference Range

Units: mcg/mL

Effective date: 07/27/2016

Ref. Range Notes

Reference Range: Depends on clinical use.

• Anticonvulsant: 5.0-20.0 mcg/mL

Interpretation:

Most individuals display optimal response to topiramate with serum levels 5.0 to 20.0 mcg/mL when used to control seizures. Some individuals may respond well outside of this range, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation.

Therapeutic ranges are based on specimens drawn at trough (ie, immediately before the next dose).

Toxic levels have not been well established.

Interferences and Limitations

Cautions: This test cannot be performed on whole blood.

Ordering & Collection

Specimen Type

Blood

Collection

3 mL blood in RED TOP tube

Unacceptable: Gold SST/gel separator tubes

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 28 days.

Quantity

Requested: 1 mL serum
Minimum: 0.5 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum.

Sendouts:

• Order Mayo Test: TOPI.
• Interfaced: Yes.

Stability: Refrigerated (Preferred): 28 days; Frozen: 28 days; Ambient: 28 days.

Misc Sendout

Performance

Lab Department

Sendouts Mayo Lab (RF)(MARF)

Frequency

Performed: Monday - Saturday. Report Available: 1-2 days.

Available STAT?

No

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901

Billing & Coding

CPT Codes

80201

LOINC

17713-9

Interfaced Order Code

UOW2053

Interfaced Result Code

UOW2053