LGI1 and CASPR2 IgG Antibodies, Serum (Sendout)

General Information

Lab Name

Lab Code

RRLGC2

Epic Name

LGI1 and CASPR2 IgG Antibodies, Serum (Sendout)

External Test Id

2009460

Description

Ordering Recommendation:

Aid in diagnosis of leucine-rich glioma inactivated 1 protein (LGI1) antibody disorders associated with limbic encephalitis, hyponatremia, and myoclonic movements. Disorders are rarely associated with tumors.
Aid in diagnosis of contactin associated protein 2 (CASPR2) antibody disorders associated with acquired neuromyotonia, limbic encephalitis, painful neuropathy, and Morvan syndrome.
Use to manage antibody-positive (LGI1 or CASPR2) individual following immunotherapy and/or plasmapheresis

Test Algorithm: If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be performed. If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be performed. Additional charges apply.

Ordering Note: This test may be performed reflexively from VGKC Antibody w/ Reflex, Serum (Sendout) [RVGKCA] or ordered directly. Do not order concurrently with RVGKCA.

Synonyms

2009460, CASPR2, Contactin-Associated Protein-2 Antibody IgG CBA-IFA, Leucine-Rich Glioma-Inactivated Protein 1 Antibody IgG CBA-IFA, LGI1

Components

Code	Name
RCSP2S	CASPR2 IgG Antibody Screen, Serum
RLGI1S	LGI1 IgG Antibody Screen, Serum

Interpretation

Method: Semi-Quantitative Indirect Fluorescent Antibody
Reference Range: See individual components

Ordering & Collection

Specimen Type: Blood
Collection: 3 mL blood in RED TOP tube or GOLD SST
Handling Instructions: Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum while awaiting transport. Ship with an ice pack.

Stability: Refrigerated (Preferred): 2 weeks; Frozen: 1 year (avoid repeat freeze/thaw cycles); Ambient: 48 hours.

Unacceptable Conditions: CSF or plasma. Contaminated, hemolyzed, or severely lipemic specimens.
Quantity: Requested: 1 mL serum
Minimum: 0.2 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum.

Sendouts:

Order ARUP test: 2009460
Interfaced: Yes [Interface: 602; Department: ARPR]

Stability: Refrigerated (Preferred): 2 weeks; Frozen: 1 year (avoid repeat freeze/thaw cycles); Ambient: 48 hours.

Unacceptable Conditions: CSF or plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Misc Sendout

Performance

Lab Department

Sendouts ARUP Lab (RF)(ARPR)

Frequency

Performed: Wed. Reported: 1-8 days from sample receipt at ARUP Laboratories.

Available STAT?

Performing Location(s)

Sendout	ARUP Laboratories, Inc. 800-522-2787 500 Chipeta Way Salt Lake City, UT 84108

Billing & Coding

CPT Codes: 86255x2
LOINC: 18727-8