Renin Activity (Sendout)

General Information

Lab Name

Lab Code

RRENA

Epic Name

Renin Activity (Sendout)

External Test Id

PRA

Description

Useful For: Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome).

Patient Preparation: The plasma renin activity cannot be interpreted if the patient is being treated with spironolactone (Aldactone). Spironolactone (Aldactone) should be discontinued for 4-6 weeks before testing.

Synonyms

Plasma Renin Activity, PRA

Components

Code	Name
RSITE	Renin Activity Specimen Site
RSTIM	Renin Act Stimulation Interval
RREN	Renin Activity

Interpretation

Method

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reference Range

See individual components

Ref. Range Notes

Ages 0-17 Years:

Age	Mean	Range
0-2 years:	4.6 ng/mL/hour¹	1.4-7.8 ng/mL/hour
3-5 years:	2.5 ng/mL/hour¹	1.5-3.5 ng/mL/hour
6-8 years:	1.4 ng/mL/hour¹	0.8-2.0 ng/mL/hour
9-11 years:	1.9 ng/mL/hour¹	0.9-2.9 ng/mL/hour
12-17 years:	1.8 ng/mL/hour¹	1.2-2.4 ng/mL/hour

Mean data not standardized as to time of day or diet. Infants were supine, children sitting.

Age > or = 18:

Na-depleted, upright (peripheral vein specimen):

Age	Mean	Range
18-39 years:	10.8 ng/mL/hour	2.9-24.0 ng/mL/hour
> or =40 years:	5.9 ng/mL/hour	2.9-10.8 ng/mL/hour

Na-replete, upright (peripheral vein specimen):

Age	Mean	Range
18-39 years:	1.9 ng/mL/hour	< or =0.6-4.3 ng/mL/hour
> or =40 years:	1.0 ng/mL/hour	< or =0.6-3.0 ng/mL/hour

References:

Stalker HP, Holland NH, Kotchen JM, Kotchen TA: Plasma renin activity in healthy children. J Pediatr 1976;89:256-258.

Ordering & Collection

Specimen Type: Plasma
Collection: Prechill a 7 mL LAVENDER TOP tube. Draw blood from a patient in a seated position into the pre-chilled Lavender top tube, mix, and immediately place in an ice-water bath. Transport to the laboratory without delay.
Handling Instructions: This test cannot be added on to a sample already in the lab due to the specific collection and processing requirements. A fresh blood collection is required.
Quantity: Requested: 2 mL plasma
Minimum: 1.2 mL plasma

Processing

Receiving Instructions

Refrigerate specimen during centrifugation. Immediately transfer plasma to a separate plastic vial and freeze at -20°C.

If a refrigerated centrifuge is unavailable, chill the centrifuge carriers. Centrifuge specimen for 5 minutes or less, then promptly transfer plasma.

Result-at-entry:

RSITE (Renin Activity Specimen Site): <enter the specimen collection site, or INP if not provided.>
- Examples: PERP (peripheral), RARM (Right Arm), LARM (Left Arm), ANTE (Antecubital), LANT (Left Antecubital), RANT (Right Antecubital).
RSTIM (Renin Act Stimulation Interval): <enter the stimulation interval, or INP if not provided.>
- Examples: BASE (Baseline), or free text (10 minutes post, etc.).

Sendouts:

Order Mayo Test: PRA.
If collection is site specific, indicate the collection site under "Report Notes" in MayoAccess order.

Stability: Frozen (critical): 14 days; Refrigerated: Unacceptable; Ambient: Unacceptable.

Misc Sendout

Performance

Lab Department

Sendouts Mayo Lab (FZ)(MAFZ)

Frequency

Performed: Monday - Friday at 1 p.m. Analytic Time: 2 days.

Available STAT?

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901

Billing & Coding

CPT Codes: 84244
LOINC: 2915-7
Interfaced Order Code: UOW1719