Paraneoplastic Autoantibody Evaluation, Serum (Sendout)

Useful For:

• Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
• Directing a focused search for cancer
• Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis
• Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
• Monitoring the immune response of seropositive patients in the course of cancer therapy
• Detecting early evidence of cancer recurrence in previously seropositive patients
• For a complete list of tests and potential reflex tests included in this panel, refer to the Mayo Paraneoplastic Evaluation Algorithm - Serum

Ordering Notes:

• Non-orderable battery included in the Paraneoplastic Autoantibody Evaluation, Serum (Sendout) [RPNPV] package.
• Individual antibody tests within the Paraneoplastic Autoantibody Evaluation are available for patients who have previously tested positive for those antibodies within the past five years at a Mayo laboratory. Refer to Mayo test: Neuroimmunology Antibody Follow-up, Serum.

Centrifuge samples and transfer 4 mL serum (2 mL minimum) into the RPNPEV aliquot. If specimen volume allows, aliquot 1 mL serum into a separate plastic vial for Immunology (UW437). Prioritize the sendout test (RPNPEV).

• RPNPEV: Refrigerate 4 mL serum (2 mL minimum) in the Sendouts Mayo rack.
• UW437: Freeze 1 mL serum at -20°C in Immunology rack.

If individual antibodies are requested (with a previous positive result within the last 5 years at Mayo), refer to separate test guide #982 (Neuroimmunology Follow-up, PNEFS).

Sendouts:

• Order Mayo Test: PAVAL
• Interfaced: Yes [Interface: 601; Worksheet: MARF]

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, lipemia, icterus.