Paraneoplastic Autoantibody Evaluation, Serum (Sendout)

General Information

Lab Name

Paraneoplastic AutoAb Evaluation (Sendout)

Lab Code

RPNPEV

Epic Ordering

Paraneoplastic Autoantibody Evaluation (Sendout)

External Test Id

PAVAL

Description

Useful For:

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
Directing a focused search for cancer
Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis
Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
Monitoring the immune response of seropositive patients in the course of cancer therapy
Detecting early evidence of cancer recurrence in previously seropositive patients
For a complete list of tests and potential reflex tests included in this panel, refer to the Mayo Paraneoplastic Evaluation Algorithm - Serum

Ordering Notes:

Non-orderable battery included in the Paraneoplastic Autoantibody Evaluation, Serum (Sendout) [RPNPV] package.
Individual antibody tests within the Paraneoplastic Autoantibody Evaluation are available for patients who have previously tested positive for those antibodies within the past five years at a Mayo laboratory. Refer to Mayo test: Neuroimmunology Antibody Follow-up, Serum.

Synonyms

PAVAL

Components

Code	Name
RANN1	Anti Neuronal Nuclear Antibody 1
RANN2	Anti Neuronal Nuclear Antibody 2
RANN3	Anti Neuronal Nuclear Antibody 3
RAGNA1	Anti Glial Nuclear Antibody 1
RPCA1	Purkinje Cell Cytoplasmic Antibody 1
RPCA2	Purkinje Cell Cytoplasmic Antibody 2
RPCATR	Purkinje Cell Cytoplasmic Antibody Tr
RAMPHS	Amphiphysin Antibody
RCRMP	CRMP 5 IgG
RCCPQ	P/Q Type Calcium Channel Ab
RNVGCK	Neuronal (V_G) K Channel Ab
RPNINT	Paraneoplastic AutoAb Interp

Interpretation

Method: Panel and reflex tests include the following methods: Immunofluorescence assay (IFA), Cell-binding assay (CBA), Western blot (WB), Radioimmunoassay (RIA), Immunoblot (IB)
Reference Range: See individual components

Ordering & Collection

Specimen Type: Blood
Collection: 12 mL blood in RED TOP tubes or GOLD SST
Handling Instructions
Quantity: requested: 4 mL serum
minimum: 2 mL serum

Processing

Processing

Centrifuge samples and transfer 4 mL serum (2 mL minimum) into the RPNPEV aliquot. If specimen volume allows, aliquot 1 mL serum into a separate plastic vial for Immunology (UW437). Prioritize the sendout test (RPNPEV).

RPNPEV: Refrigerate 4 mL serum (2 mL minimum) in the Sendouts Mayo rack.
UW437: Freeze 1 mL serum at -20°C in Immunology rack.

If individual antibodies are requested (with a previous positive result within the last 5 years at Mayo), refer to separate test guide #982 (Neuroimmunology Follow-up, PNEFS).

Sendouts:

Order Mayo Test: PAVAL
Interfaced: Yes [Interface: 601; Worksheet: MARF]

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, lipemia, icterus.

Performance

LIS Dept Code

Sendouts Mayo Lab (RF) (MARF)

Performing Location(s)

Sendout	Mayo Clinic Laboratories 800-533-1710 200 First Street Southwest Rochester, MN 55901

Frequency

Performed: Monday - Sunday. Reflex tests: Varies. Report Available: 10-17 days from sample receipt at the performing laboratory.

Available STAT?

Billing & Coding

CPT codes: 83519, 86256x9, 86596
LOINC: 43104-9
Interfaced Order Code: UOW2218