Paraneoplastic Autoantibody Evaluation, Serum (Sendout)
General Information
- Lab Name
- Paraneoplastic AutoAb Evaluation (Sendout)
- Lab Code
- RPNPEV
- Epic Name
- Paraneoplastic Autoantibody Evaluation (Sendout)
- External Test Id
- PAVAL
- Description
Useful For:
- Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
- Directing a focused search for cancer
- Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis
- Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
- Monitoring the immune response of seropositive patients in the course of cancer therapy
- Detecting early evidence of cancer recurrence in previously seropositive patients
- For a complete list of tests and potential reflex tests included in this panel, refer to the Mayo Paraneoplastic Evaluation Algorithm - Serum
Ordering Notes:
- Non-orderable battery included in the Paraneoplastic Autoantibody Evaluation, Serum (Sendout) [RPNPV] package.
- Individual antibody tests within the Paraneoplastic Autoantibody Evaluation are available for patients who have previously tested positive for those antibodies within the past five years at a Mayo laboratory. Refer to Mayo test: Neuroimmunology Antibody Follow-up, Serum.
- Synonyms
- PAVAL
- Components
-
Code Name RANN1 Anti Neuronal Nuclear Antibody 1 RANN2 Anti Neuronal Nuclear Antibody 2 RANN3 Anti Neuronal Nuclear Antibody 3 RAGNA1 Anti Glial Nuclear Antibody 1 RPCA1 Purkinje Cell Cytoplasmic Antibody 1 RPCA2 Purkinje Cell Cytoplasmic Antibody 2 RPCATR Purkinje Cell Cytoplasmic Antibody Tr RAMPHS Amphiphysin Antibody RCRMP CRMP 5 IgG RCCPQ P/Q Type Calcium Channel Ab RNVGCK Neuronal (V_G) K Channel Ab RPNINT Paraneoplastic AutoAb Interp
Interpretation
- Method
Panel and reflex tests include the following methods: Immunofluorescence assay (IFA), Cell-binding assay (CBA), Western blot (WB), Radioimmunoassay (RIA), Immunoblot (IB)
- Reference Range
- See individual components
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
12 mL blood in RED TOP tubes or GOLD SST
- Quantity
-
Requested: 4 mL serum
Minimum: 2 mL serum
Processing
- Receiving Instructions
Centrifuge samples and transfer 4 mL serum (2 mL minimum) into the RPNPEV aliquot. If specimen volume allows, aliquot 1 mL serum into a separate plastic vial for Immunology (UW437). Prioritize the sendout test (RPNPEV).
- RPNPEV: Refrigerate 4 mL serum (2 mL minimum) in the Sendouts Mayo rack.
- UW437: Freeze 1 mL serum at -20°C in Immunology rack.
If individual antibodies are requested (with a previous positive result within the last 5 years at Mayo), refer to separate test guide #982 (Neuroimmunology Follow-up, PNEFS).
Sendouts:
- Order Mayo Test: PAVAL
- Interfaced: Yes [Interface: 601; Worksheet: MARF]
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, icterus.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (RF)(MARF)
- Frequency
- Performed: Monday - Sunday. Reflex tests: Varies. Report Available: 10-17 days from sample receipt at the performing laboratory.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 86255x9
- LOINC
- 43104-9
- Interfaced Order Code
- UOW2218