Macroprolactin

Useful For:

• Determining biologically active levels of prolactin, in asymptomatic patients with elevated prolactin levels
• Ruling out the presence of macroprolactin

Total Prolactin: Electrochemiluminescent Immunoassay

Prolactin, Unprecipitated: Polyethylene Glycol (PEG) Precipitation Followed by Electrochemiluminescent Immunoassay

Prolactin, Total:

• Males/Females <18 years: not established
• Males > or = 18 years: 4.0-15.2 ng/mL
• Females > or = 18 years: 4.8-23.3 ng/mL

Prolactin, Unprecipitated:

• Males/Females <18 years: not established
• Males > or = 18 years: 2.7-13.1 ng/mL
• Females > or = 18 years: 3.4-18.5 ng/mL

When the percent of the precipitated (complexed) prolactin fraction of the total prolactin is 60% or less, the result is considered negative for macroprolactin.

Refer to Mayo's website for additional interpretive information: Macroprolactin, Serum: Clinical & Interpretive

Patient Preparation: For 12 hours before this test, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collect 3 mL blood in RED TOP tube or GOLD SST

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate.

Sendouts, order Mayo Test: MCRPL

Stability: Refrigerated (preferred): 7 days; Frozen: 90 days; Ambient: 24 hours.