Prenatal Integrated Screen, 1st Trimester (Sendout)

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General Information

Lab Name
Prenatal Integrated Screen, 1st Trimester (Sendout)
Lab Code
RINTP1
Epic Name
Prenatal Integrated Screen, 1st Trimester (Sendout)
External Test Id
3000147
Description

Ordering Recommendation: First-trimester screening test for trisomy 21 (Down syndrome), trisomy 18 (Edwards), and open neural tube defects. Risks determined using a combination of first- and second-trimester serum markers, with or without first-trimester nuchal translucency measurement. Risks provided after testing is completed for second-trimester specimen, Prenatal Integrated Screen, 2nd Trimester (Sendout) [RINTP2].

Test Algorithm: The first specimen of an Integrated Prenatal Serum Screening is used to measure PAPP-A. A final interpretative report will be available when the second specimen test results are complete.

Patient Preparation:

  • Specimen must be drawn between 10 weeks, 0 days and 13 weeks, 6 days gestation.
  • If gestational age is based on Crown-rump length (CRL), the specimen must be collected when the CRL is between 32.4-83.9 mm.

Ordering Requirements:

  • If an NT measurement is obtained: The date of ultrasound, the CRL measurement, the nuchal translucency (NT) measurement, and the name and certification number of the sonographer is required. NT must be measured when the CRL is between 38-83.9 mm.
  • If no NT measurement is obtained: A due date or CRL measurement with the date of ultrasound is required.
  • For orders not placed in Epic, an ARUP Maternal Serum Testing Patient History Form is required.
References
Forms & Requisitions
Synonyms
3000147, First Trimester Screening, Maternal Serum Integrated Screen, PRINT1, PRSQ1T, PRSQ1X, RSEQM1, trisomy
Components
Code Name
RPDOB Patient Date of Birth
RPWGT Patient Weight
RPWTU Weight Units (lbs or kg)
RPEDD EDD (Estimated Due Date)
RPEDM EDD Dating Method
RPLMP LMP (Last Menstrual Period)
RPFET Number of Fetuses
RPMOT Monochorionic Twins?
RPRAC Patient Race
RPIDD Insulin Dependent Diabetes?
RPSMK Current Cigarette Smoker?
RPVCM Patient taking Valproic Acid or Carbamazepine?
RPTRI Previous Trisomy Pregnancy?
RPNTD Family History of NTD (Neural Tube Defects)?
RPIVF In Vitro Fertilization (IVF) Pregnancy?
RPDOA Donor Egg Age at Harvest?
RPRPT Repeat Specimen?
RDOUS Date of Ultrasound
RPCRL Crown Rump Length (CRL)
RNUCT Nuchal Translucency (NT)
RPSON Sonographer Name
RPCER Sonographer Certification Number
RPMDN Reading MD Name
RPMCT Reading MD Certification Number
RPAPPA PAPP A Maternal
RPNUCT Nuchal Translucency (NT)
RPNUCB Nuchal Translucency (NT), Twin B
RPINTP Maternal Screen Interpretation
RPAGED Patient Age at Delivery
RPMWGT Patient Weight
RPSEDD Estimated Due Date
RPGEST Gestational Age Calculated at Collection
RPDATM Dating Method
RPNFET Number of Fetuses
RPSMOK Smoker
RPFHXA Family History of Aneuploidy
RPSPEC Initial or Repeat Specimen
RPCRLA Crown Rump Length
RPCRLB Crown Rump Length, Twin B
RPSONC Sonographer Certification Number
RPSONN Sonographer Name
RPUSDT Ultrasound Date
RPSMP2 Best Date to Draw Second Sample
RPINTL Prenatal Integrated Screen, 1st Trimester Performing Lab

Interpretation

Method

Quantitative Chemiluminescent Immunoassay

Reference Range
See individual components
Ref. Range Notes

Refer to report.

References

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in GOLD SST or RED TOP tube

Forms & Requisitions
Handling Instructions

Outside Laboratories:

  • Centrifuge sample and transfer 0.5 mL (0.3 mL min) serum to a separate plastic vial. Serum must be separated from cells within 2 hours of collection. Refrigerate serum.
  • Submit a completed ARUP Maternal Serum Testing Patient History Form along with the DLMP requisition.* Failure to provide the required information may result in test delays.
    • *Use client-specific requisition when available. To obtain a client-specific requisition, contact Client Support Services via email at: commserv@uw.edu.

Stability (after separation from cells): Refrigerated (preferred): 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles); Ambient: 72 hours.

Unacceptable Conditions: Plasma, hemolyzed specimens.

Quantity
Requested: 0.5 mL serum
Minimum: 0.3 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer 0.5 mL (0.3 mL minimum) serum to a separate plastic vial. Serum must be separated from cells within 2 hours of collection. Refrigerate serum.

Sendouts:

  • Order ARUP Test: 3000147.
  • Interfaced: Yes. [Interface: 602; Department: ARPR]
  • For orders placed in Epic: The answers to the order questions will file from Epic to ARUP via the interface.
  • For orders not placed in Epic: A completed ARUP Patient History Form is required. If not provided, send an HC1 Task to CSS asking them to follow up with the client to obtain the form.

Stability (after separation from cells): Refrigerated (preferred): 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles); Ambient: 72 hours.

Unacceptable Conditions: Plasma, hemolyzed specimens.

Misc Sendout

Performance

Lab Department
Sendouts ARUP Lab (RF)(ARPR)
Frequency
Performed: Sunday - Saturday. Reported: 2-4 days from sample receipt at ARUP. Missing information may further delay testing.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

CPT Codes
84163
LOINC
48798-3