Cytomegalovirus (CMV) Antibodies, IgM and IgG (Sendout)

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General Information

Lab Name
CMV IgM and IgG Antibodies, Serum (Sendout)
Lab Code
RCMVMG
Epic Name
CMV IgM and IgG Antibodies, Serum (Sendout)
External Test Id
CMVAB
Description

Useful For: Aiding in determining the serological status to cytomegalovirus.

References
Synonyms
CMV IgG/IgM, CMV IgM, CMVAB, CMVP, CMVSGM, Cytomegalo Inclusion Disease (CMID), Torch IgG, Torch IgM
Components
Code Name
RCMVM Cytomegalovirus IgM Antibody, Serum
RCMVG Cytomegalovirus IgG Antibody, Serum

Interpretation

Method

Electrochemiluminescence Immunoassay (ECLIA)

Reference Range
See individual components
Ref. Range Notes

Reference Values:

CMV IgM: Negative
CMV IgG: Negative

Reference values apply to all ages.

Interpretation:

Negative: Negative for cytomegalovirus (CMV) IgM and IgG. False negative results may occur in immunocompromised patients.
Borderline: Recommend follow-up testing in 10 to14 days if clinically indicated.
Positive IgG: CMV IgG antibodies detected, which indicate recent or remote infection. These individuals may transmit CMV to susceptible individuals through blood and tissue products.
Positive IgM: CMV IgM antibodies detected, which may indicate active or recent infection. Low level IgM antibodies may persist for more than 12 months following disease resolution.
Interferences and Limitations

Cautions:

Sera collected very early during the acute stage of infection may have undetectable levels of cytomegalovirus (CMV) IgM or IgG.

    Performance characteristics have not been evaluated in immunocompromised or immunosuppressed individuals. Immunocompromised patients may have impaired immune responses and nonreactive IgM and IgG results may be due to delayed seroconversion and, therefore, do not rule out current infection.

      The CMV IgM and IgG results should not be used alone to diagnose CMV infection. Results should be considered in conjunction with clinical presentation, patient history and other laboratory findings.

        The performance characteristics of these assays have not been evaluated or established for blood or plasma donors, cord blood, patients undergoing immunosuppressive therapy, patients with other disorders leading to immune suppression, or for testing of neonates.

          Immune complexes or other immunoglobulin aggregates present in patient specimens may cause increased nonspecific binding and produce false-positive results.

            Potential cross-reactivity for CMV IgM may occur with specimens positive for Epstein-Barr virus viral capsid antigen IgM. Potential cross-reactivity with autoimmune markers and antibodies against influenza vaccination could not be ruled out.

              Potential cross-reactivity for CMV IgG with varicella-zoster virus IgG, measles IgG, mumps IgG and parvovirus B19 IgG and could not be ruled out. The potential cross-reactivity with E. coli and autoimmune markers could not be ruled out.

                Samples should not be taken from patients receiving therapy with high biotin doses (ie, > 5 mg/day) until at least 8 hours following the last biotin administration.

                Ordering & Collection

                Specimen Type
                Blood
                Collection

                3 mL blood in RED TOP tube or GOLD SST

                Handling Instructions

                Outside Laboratories: Centrifuge sample and aliquot serum to a separate vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.

                Stability: Refrigerated (preferred): 28 days; Frozen: 90 days; Ambient: 7 days.

                Reject Due To: Gross hemolysis, gross lipemia, gross icterus, heat-inactivation, or additives (eg, biocides, antioxidants).

                Quantity
                Requested: 1 mL serum
                Minimum: 0.7 mL serum

                Processing

                Receiving Instructions

                Centrifuge sample and aliquot serum to a separate vial. Refrigerate serum.

                Sendouts:

                • Order Mayo Test: CMVAB
                • Interfaced: Yes [Interface: 601; Worksheet: MARF]

                Stability: Refrigerated (preferred): 28 days; Frozen: 90 days; Ambient: 7 days.

                Reject Due To: Gross hemolysis, gross lipemia, gross icterus, heat-inactivation, or additives (eg, biocides, antioxidants).

                Misc Sendout

                Performance

                Lab Department
                Sendouts Mayo Lab (RF)(MARF)
                Frequency
                Performed: Monday through Saturday. Report Available: 1-3 days from sample receipt at Mayo Clinic Lab.
                Available STAT?
                No
                Performing Location(s)
                Sendout Mayo Clinic Laboratories (Superior Drive)
                800-533-1710

                3050 Superior Drive NW
                Rochester, MN 55901

                Billing & Coding

                CPT Codes
                86644, 86645
                LOINC
                24315-4
                Interfaced Order Code
                UOW3000