This assay includes testing for the 14-3-3 protein and tau protein by ELISA Immunoassay and RT-QuIC (real-time quaking-induced conversion). RT-QuIC identifies the disease-causing agent. T-tau protein and 14-3-3 protein are indirect markers of neurodenerative disease.
Ordering Requirements:
Code | Name |
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RCCJDR | CJD Result |
RCCJDI | CJD Interp |
Reference Ranges:
RT-QuIC, CSF: | Negative |
T-tau protein, CSF: | 0-1149 pg/mL |
14-3-3 protein, CSF: | Negative |
5 mL SPINAL FLUID - No visible blood
Note: Contact NPDPSC at (216) 368-0587 prior to submitting blood samples. Blood is non-diagnostic and should only be sent when a familial case is suspected, or if the sample has been requested by NPDPSC.
Outside Laboratories: If no concurrent CSF testing is ordered that is to be performed by the UW Department of Laboratory Medicine and Pathology clinical laboratories, clients outside of the University system are encouraged to send samples directly to National Prion Disease Pathology Surveillance Center (Sample Submission Information).
Failure to follow the guidelines below for submitting CJD samples may result in significant processing delays.
LMR Approval Exception for Outside Orders: Outside clients should be discouraged from sending samples for CJD without concurrent CSF orders for in-house testing. However, if the sample has already been shipped to/received by UW from an outside facility, DLMP will accept the order and forward to NPDPSC.
Specimen Processing Services (SPS)/Microbiology Set up:
Sendouts:
Stability: Frozen -70°C (preferred): 2 weeks; Refrigerated: 2 weeks.
Sendout |
National Prion Disease Pathology Surveillance Center
216-368-0587 2085 Adelbert Road |
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