Aquaporin-4 IgG Antibody, Serum (Sendout)
General Information
- Lab Name
- Aquaporin-4 IgG Antibody, Serum (Sendout)
- Lab Code
- RAQP4A
- Epic Name
- Aquaporin-4 IgG Antibody, Serum (Sendout)
- External Test Id
- NMOFS
- Description
Useful For:
- Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
- Diagnosis of autoimmune AQP4 channelopathy
- Diagnosis of neuromyelitis optica (NMO)
- Distinguishing NMOSD from multiple sclerosis early in the course of disease
Testing Algorithm: If the FACS assay is positive at screening dilution, FACS Titer Assay is performed at an additional charge.
- Synonyms
- AQP, AQP4, Aquaporin, Devic's Antibody, NMO (Neuromyelitis Optica), NMO-IgG, NMOFS, Optic Neuritis Antibody, Optic-Spincal MS Ab, Soft-NMOS, Transverse Myelitis Antibody, Vision Loss Antibody
- Components
-
Code Name RNMAQS Aquaporin-4 FACS Screen RNMAQT Aquaporin-4 FACS Titer
Interpretation
- Method
Flow Cytometry / Fluorescence-Activated Cell Sorting Assay (FACS)
- Reference Range
- See individual components
- Ref. Range Notes
Interpretation: A positive value is consistent with a neuromyelitis optica spectrum disorder (NMOSD) and justifies initiation of appropriate immunosuppressive therapy at the earliest possible time. This allows early initiation and maintenance of optimal therapy. Recommend follow-up in 3 to 6 months if NMOSD is suspected.
This autoantibody is not found in healthy subjects.
- Interferences and Limitations
Cautions: AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
10 mL blood in RED TOP tube (preferred)
Also acceptable: GOLD TOP SST
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate vial. Refrigerate serum.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
- Quantity
-
Requested: 3 mL serum
Minimum: 2 mL serum
Processing
- Receiving Instructions
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: NMOFS.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (RF)(MARF)
- Frequency
- Performed: Monday, Tuesday, Thursday. Report Available: 5-8 days.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 86053
- LOINC
- 43638-6
- Interfaced Order Code
- UOW4502