ADAMTS13 Activity (Sendout)

General Information

Lab Name

ADAMTS13 Activity (Sendout)

Lab Code

RADM13

Epic Name

ADAMTS 13 Activity (Sendout)

External Test Id

3260-01

Description

Test Information: ADAMTS13 activity is measured by a Fluorescence Resonance Transfer (FRET) Assay in which fluorescence is detected when a synthetic von Willebrand Factor peptide (VWF73) is cleaved by ADAMTS13.

ADAMTS13 is a plasma protein that cleaves ultra-large VWF multimers, thus regulating the interaction of platelets with von Willebrand. Low ADAMTS13 activity is found in patients with thrombotic thrombocytopenia purpura (TTP). Very low levels of activity can be seen in congenital TTP, whereas modestly decreased levels have been reported in a number of clinical settings. ADAMTS13 activity levels may help differentiate TTP from other microthrombolytic disorders such as HUS or atypical HUS.

Note: If the activity level is <30%, the ADAMTS 13 Inhibitor and ADAMTS 13 Antibody may be performed at additional charge.

Forms & Requisitions

Bloodworks Northwest Platelet Immunology Laboratory Requisition

Synonyms

3260-01, ADAMTS13, ATS-13, TTP, Von Willebrand Factor Protease Activity & Inhibitor for Thrombotic Thrombocytopenia Purpura, VWF Metalloproteinase

Components

Code	Name
RADMNA	ADAMTS13 Protease Act (Sendout)
RADMIA	ADAMTS13 Inhibition (Sendout)
RADMAB	ADAMTS13 Antibody (Sendout)
RADMSC	ADAMTS13 Specific Comment (Sendout)
RADMCM	ADAMTS13 Comments (Sendout)
S2AD13	ADAMTS13 Activity Testing Lab