Metanephrines, Fractionated, Free, Plasma
General Information
- Lab Name
- Metanephrines, Plasma
- Lab Code
- PLMET
- Epic Name
- Metanephrines, Plasma
- Description
The most sensitive test to rule-out pheochromocytoma is plasma free metanephrines (PLMET). See also Metanephrines, Fractionated, Urine (RUFMET). For a recent review of the biochemical diagnosis of pheochromocytoma, see Pacak K et al. Nature Clin Pract Endocrinol Metab 2007; 3:92-102.PMID: 17237836
The concentration of metanephrine and normetanephine is determined by solid phase extraction followed by liquid chromatography-tandem mass spectrometry. The reportable range is 0.2 to 80.0 nmol/L for metaneprhine and normetaneprhine, respectively, with imprecision between 3.3 and 8.2 %CV.
- Synonyms
- Fractionated Metanephrines-Plasma, Free Metanephrines-Plasma, MEN, MEN IIA, MEN IIB, Multiple Endocrine Neoplasia, Neuroendocrine, NMN (Normetanephrines)-plasma, paraganglioma, Phaeochromocytoma, Pheochromocytoma, Soft-PMET
- Components
-
Code Name MN Metanephrine NMN Normetanephrine PLMETM Metanephrines Method, Plasma
Interpretation
- Method
Serum solid phase extraction. Isotope dilution liquid chromatography mass spectrometry
- Reference Range
- See individual components
Ordering & Collection
- Specimen Type
- Plasma
- Collection
-
3 mL blood in a LAVENDER TOP (EDTA) tube
- Quantity
-
Requested: 1.5 mL EDTA plasma
Minimum: 0.5 mL EDTA plasma
Processing
- Receiving Instructions
Centrifuge & remove plasma - Freeze in plastic aliquot tube at -20˚C.
- Misc Sendout
Performance
- Lab Department
- Chemistry, University(CHU)
- Frequency
- Monday
- Available STAT?
- No
- Performing Location(s)
-
UW-MT Chemistry, General
206-520-4600Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195
Billing & Coding
- CPT Codes
- 83835
- LOINC
- 43108-0
- Interfaced Order Code
- UOW2604