17-Hydroxyprogesterone (Sendout)

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General Information

Lab Name
17_Hydroxyprogesterone
Lab Code
OHPROG
Epic Name
17-Hydroxyprogesterone
External Test Id
OHPG
Description

Useful For:

  • The analysis of 17-hydroxyprogesterone (17-OHPG) is 1 of the 3 analytes along with cortisol and androstenedione, that constitutes the best screening test for congenital adrenal hyperplasia (CAH), caused by either 11- or 21-hydroxylase deficiency.
  • Analysis for 17-OHPG is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH
Synonyms
17 Alphahydroxyprogesterone, 17 Hydroxy Progesterone, 17-OH Progesterone, 17OH Progesterone, Hydroxyprogesterone, OHPG, Serum
Components

Interpretation

Method

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reference Range
Units: ng/dL
Ref. Range Notes

Reference Values:

Children:

Preterm Infants: May exceed 630 ng/dL, however, it is uncommon to see levels reach 1,000 ng/dL
Term infants, 0-28 days: <630 ng/dL
Levels fall from newborn (<630 ng/dL) to prepubertal gradually within 6 months.
Prepubertal males: <110 ng/dL
Prepubertal females: <100 ng/dL

Adults:

Males: <220 ng/dL
Females, Follicular: <80 ng/dL
Females, Luteal: <285 ng/dL
Females, Postmenopausal: <51 ng/dL

Note: For pregnancy reference ranges, see: Soldin OP, Guo T, Weiderpass E, et al: Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry. Fertil Steril 2005 Sept;84(3):701-710

Interferences and Limitations

Cautions: At birth the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-gonadal axis are activated and adrenal and sex steroid levels are high. In preterm infants the elevations can be even more pronounced due to illness and stress. As a result, preterm infants may occasionally have 17-hydroxyprogesterone levels of up to 1,000 ng/dL. Term infants (0-28 days) will have levels <630 ng/dL. These then fall over the following 1 to 6 months to prepubertal levels of <110 ng/dL (males) and <100 ng/dL (females).

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in RED TOP tube

  • Pediatric: 1 full plain RED microcontainer

Unacceptable: Serum gel tubes or any tube with anticoagulant.

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 7 days.

Reject Due To: Gross hemolysis, gross lipemia, serum from gel tube. Gross icterus is accepted.

Quantity
Requested: 0.6 mL serum
Minimum: 0.25 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Sendouts:

  • Order Mayo Test: OHPG.
  • Interfaced: Yes.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 7 days.

Reject Due To: Gross hemolysis, gross lipemia, serum from gel tube. Gross icterus is accepted.

Misc Sendout

Performance

Lab Department
Sendouts Mayo Lab (RF)(MARF)
Frequency
Performed: Monday-Friday. Report Available: 2-5 days.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901

Billing & Coding

CPT Codes
83498
LOINC
1668-3
Interfaced Order Code
UOW1897
Interfaced Result Code
UOW1897