17-Hydroxyprogesterone (Sendout)

General Information

Lab Name

17_Hydroxyprogesterone

Lab Code

OHPROG

Epic Name

17-Hydroxyprogesterone

External Test Id

OHPG

Description

Useful For:

The analysis of 17-hydroxyprogesterone (17-OHPG) is 1 of the 3 analytes along with cortisol and androstenedione, that constitutes the best screening test for congenital adrenal hyperplasia (CAH), caused by either 11- or 21-hydroxylase deficiency.
Analysis for 17-OHPG is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH

***Test Status Notification: Effective 03/20/2026, results will be delayed past the published turnaround time due to instrument issues at Mayo Clinic Laboratories. Specimens will be stabilized upon arrival and processed in the order received. Orders may take up to 10 days to result. The expected duration of this delay is 20 days or more.***

Synonyms

17 Alphahydroxyprogesterone, 17 Hydroxy Progesterone, 17-OH Progesterone, 17OH Progesterone, Hydroxyprogesterone, OHPG, Serum

Components

Interpretation

Method

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reference Range

Units: ng/dL

Effective date: 08/06/2002

Ref. Range Notes

Reference Values:

Children:

Preterm Infants:	May exceed 630 ng/dL, however, it is uncommon to see levels reach 1,000 ng/dL
Term infants, 0-28 days:	<630 ng/dL
	Levels fall from newborn (<630 ng/dL) to prepubertal gradually within 6 months.
Prepubertal males:	<110 ng/dL
Prepubertal females:	<100 ng/dL

Adults:

Males:	<220 ng/dL
Females, Follicular:	<80 ng/dL
Females, Luteal:	<285 ng/dL
Females, Postmenopausal:	<51 ng/dL

Note: For pregnancy reference ranges, see: Soldin OP, Guo T, Weiderpass E, et al: Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry. Fertil Steril 2005 Sept;84(3):701-710

Interferences and Limitations

Cautions: At birth the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-gonadal axis are activated and adrenal and sex steroid levels are high. In preterm infants the elevations can be even more pronounced due to illness and stress. As a result, preterm infants may occasionally have 17-hydroxyprogesterone levels of up to 1,000 ng/dL. Term infants (0-28 days) will have levels <630 ng/dL. These then fall over the following 1 to 6 months to prepubertal levels of <110 ng/dL (males) and <100 ng/dL (females).

Ordering & Collection

Specimen Type

Blood

Collection

3 mL blood in RED TOP tube

Pediatric: 1 full plain RED microcontainer

Unacceptable: Serum gel tubes or any tube with anticoagulant.

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 7 days.

Reject Due To: Gross hemolysis, gross lipemia, serum from gel tube. Gross icterus is accepted.

Quantity

Requested: 0.6 mL serum
Minimum: 0.25 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Sendouts:

Order Mayo Test: OHPG.
Interfaced: Yes.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 7 days.

Reject Due To: Gross hemolysis, gross lipemia, serum from gel tube. Gross icterus is accepted.

Misc Sendout

Performance

Lab Department

Sendouts Mayo Lab (RF)(MARF)

Frequency

Performed: Monday-Friday. Report Available: 2-5 days.

Available STAT?

Performing Location(s)

Sendout	Mayo Clinic Laboratories 800-533-1710 200 First Street Southwest Rochester, MN 55901

Billing & Coding

CPT Codes: 83498
LOINC: 1668-3
Interfaced Order Code: UOW1897
Interfaced Result Code: UOW1897