Family Variant Analysis Relative

General Information

Lab Name

Family Variant Analysis Relative

Lab Code

FAMVRE

Epic Name

Family Variant Analysis Relative

Description

The Family Variant Classification test is designed for individuals who have a clinically identified variant of uncertain significance. The service is designed to assist individuals by using several strategies to find information about variants using family data. The service will identify the presence or absence of a specific genetic variants a patient’s family by next-generation sequencing. The relative must have a >10% chance of sharing the variant. There is no limit to the number of family members who can be tested by this service. The test covers hereditary cancer genes (APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCM, FH, FLCN, MEN1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53). Approximately 50% of the time, if sufficient data from the family is collected, the service finds enough information to provide reclassification of the variant.

The service is provided as follow-up of BROCA and ColoSeq testing at no additional charge.

FindMyVariant.org

Synonyms

FindMyVariant, variant classification, variant of uncertain clinical significance, variant of uncertain significance, variant reclassification, VUS, VUS classification, VUS reclassification

Components

Code	Name
FAMVR	Familial Variant Result
FAMVIN	Familial Variant Information
FAMVCH	Familial Variant History
FAMVMT	Familial Variant Method
FAMVID	Familial Variant FamID
FAMVDI	Familial Variant Director