Family Variant Classification

General Information

Lab Name

Family Variant Analysis Proband

Lab Code

FAMVPT

Epic Ordering

Family Variant Analysis Proband

Description

The Family Variant Classification test is designed for individuals who have a clinically identified variant of uncertain significance. The service is designed to assist individuals by using several strategies to find information about variants using family data. The service will identify the presence or absence of a specific genetic variants a patient’s family by next-generation sequencing. The relative must have a >10% chance of sharing the variant. There is no limit to the number of family members who can be tested by this service. The test covers hereditary cancer genes (APC, ATM, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCM, FH, FLCN, MEN1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, SMARCA4, STK11, TP53). Approximately 50% of the time, if sufficient data from the family is collected, the service finds enough information to provide reclassification of the variant.

The service is provided as follow-up of BROCA and ColoSeq testing at no additional charge.

FindMyVariant.org

Synonyms

FindMyVariant, variant classification, variant of uncertain clinical significance, variant of uncertain significance, variant reclassification, VUS, VUS classification, VUS reclassification

Components

Code	Name
FAMVR	Familial Variant Result
FAMVIN	Familial Variant Information
FAMVCH	Familial Variant History
FAMVMT	Familial Variant Method
FAMVID	Familial Variant FamID
FAMVDI	Familial Variant Director

Interpretation

Reference Range: See individual components

Ordering & Collection

Specimen Type: Blood (FAMVPT), Saliva (FAMVRE)
Collection: 10 mL whole blood in LAVENDER TOP EDTA tube.

Also acceptable: Oragene clinical saliva collection kit, YELLOT TOP ACD, and tissue (FFPE).
Handling Instructions: Ship at room temperature overnight delivery.

OK to hold blood up to 7 days before shipping if refrigerated.

OK to hold saliva up to 14 days at room temperature before shipping and ship through standard mail.
Quantity: requested: Entire sample
minimum: 5 mL whole blood, 1 mL saliva

Processing

Processing

Performance

LIS Dept Code

Genetics (GEN)

Performing Location(s)

UW-MT	Genetics Attention: Genetics Lab Clinical lab, Room NW220 University of Washington Medical Center 1959 NE Pacific Street Seattle, WA 98195 Tel: 206-598–6429 M–F (7:30 AM–4:00 PM) Fax: 206-598–0304 Lab email: cgateam@uw.edu Tel (EXOME only): 206-543-0459	Manager Joe Bernal Genetic Counselors Angela Jacobson, MS, LGC Sandra Coe, MS,LGC Dru Leistritz, MS, LGC(EXOME testing only) Variant Review Scientist Ankita Jhuraney, PhD Sarah Paolucci, MA, MS, LGC Catherine A. Darcey, MSc Daniel W. Serber, PhD, MS, LCGC Faculty Jillian Buchan, PhD, FACMG Runjun Kumar, MD, PhD Christina Lockwood, PhD, DABCC, DABMGG Brian Shirts, MD, PhD Abbye McEwen, MD, PhD Colin Pritchard, MD, PhD Vera Paulson, MD, PhD Eric Konnick, MD, MS He Fang, PhD

Frequency

Individual variant results available within 8 weeks after sample arrives in laboratory. Reclassification result turnaround time varies.

Available STAT?

Billing & Coding

CPT codes: 81479
LOINC: 26435-8