Estradiol

General Information

Lab Name: Estradiol
Lab Code: EDOL
Epic Name: Estradiol
Description: Testing for fractionated serum estrogens may be necessary for patients suspected of having disordered steroid metabolism. If a clinician has ordered "total estrogen" follow these steps: 1) SPS calls clinician to inform them that total estrogen is not available, but estradiol is available. 2) If clinician does not want estradiol testing and wishes to pursue other estrogen testing, they must page the LMR. 3) The LMR can approve fractionated serum estrogens from Mayo (Unit code 84230) for patients with suspected disordered steroid metabolism.
Synonyms: E2, Estrogen
Components

Interpretation

Method

Chemiluminescence

Reference Range

Units: pg/mL

Effective date: 06/29/2026

Ref. Range Notes

Female:

Mid follicular: 20 - 92 pg/mL
Periovulatory: 32 - 517 pg/mL
Mid Luteal: 37 - 218 pg/mL
Post-menopause: <25 pg/mL

Male: less than 32 pg/mL

Note: Estrogen concentrations for patients undergoing gender-affirming treatment should be interpreted based on patient goals and physical response. The reference ranges provided may not align with the target goals for an affirmed gender.

Interferences and Limitations

Hormonal therapy may cause increased levels of estradiol in postmenopausal females.

Ordering & Collection

Specimen Type: Blood
Collection: Preferred: 4 mL blood in RED TOP tube

The Laboratory MUST process specimen within 2 hours of blood collection.
Handling Instructions: The Laboratory MUST process specimen within 2 hours of blood collection.
Quantity: Requested: 1 mL serum
Minimum: 0.5 mL serum

Processing

Receiving Instructions: Centrifuge and separate serum from cells within 2 hours.

Stability: 8 hrs at Room Temp; 7 days at 2 to 8°C. For long term, store at -20°C

Misc Sendout

Performance

Lab Department

Chemistry, Automated Panels(CHA)

Frequency

Daily

Available STAT?

Performing Location(s)

UW-MT	Chemistry, Automated 206-520-4600 Clinical Lab, Room NW220, University of Washington Medical Center, 1959 NE Pacific street, Seattle, WA 98195

Billing & Coding

CPT Codes: 82670
LOINC: 2243-4
Interfaced Order Code: UOW2626
Interfaced Result Code: UOW2626