Anti Neuronal Cell Antibody
General Information
- Lab Name
- Anti Neuronal Cell Ab
- Lab Code
- ANEUR
- Epic Ordering
- Anti Neuronal Cell Antibody
- Description
Elevated serum or CSF anti-neuronal cell antibody levels may help in the diagnosis of neuropsychiatric systemic lupus erythematosus (SLE). This test should not be mistaken for the assay for anti-neuronal nuclear antibodies (ANNA), which include anti-Hu, Yo, and Ri antibodies. These other tests may be ordered to evaluate some forms of paraneoplastic peripheral neuropathies associated with various malignancies, and are not currently performed at the University of Washington (they are send-out tests).
- References
- Ho RC, Thiaghu C, Ong H, Lu Y, Ho CS, Tam WW, Zhang MW. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev. 2016 Feb;15(2):124-38. doi: 10.1016/j.autrev.2015.10.003. Epub 2015 Oct 23. PMID: 26497108.
- West SG, Woodruff E, Wener MH, Kotzin BL. Neuropsychiatric Lupus Erythematosus: A 10-year prospective study on the value of diagnostic tests. Am J Med (1995) 99:153.
- Synonyms
- Components
-
Code Name ANEU Anti Neuronal Cell Ab IINTP1 Interpretation ANMTH Anti Neuronal Cell Ab Method
Interpretation
- Method
ELISA using stable, isolated neuronal membrane extracts.
- Reference Range
- See individual components
- Ref. Range Notes
Established by testing healthy blood donor samples during method validation in 1987. Confirmed in 2005, 2010, 2012, 2015, and 2018.
- References
- Ho RC, Thiaghu C, Ong H, Lu Y, Ho CS, Tam WW, Zhang MW. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev. 2016 Feb;15(2):124-38. doi: 10.1016/j.autrev.2015.10.003. Epub 2015 Oct 23. PMID: 26497108.
- West SG, Woodruff E, Wener MH, Kotzin BL. Neuropsychiatric Lupus Erythematosus: A 10-year prospective study on the value of diagnostic tests. Am J Med (1995) 99:153.
- Guidelines
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
3 mL blood in RED TOP or SST tube
- Handling Instructions
- Quantity
-
requested: 1 mL serum
minimum: 0.5 mL serum
Processing
- Processing
Freeze serum at -20°C
Stability: Freezer: Long Term; Refrig: 14 d
Performance
- LIS Dept Code
- Immunology (IMM)
- Performing Location(s)
-
UW-MT Immunology
206-520-4600Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195 - Frequency
- Monday, Wednesday
- Available STAT?
- No
Billing & Coding
- CPT codes
- 83520
- LOINC
- 32853-4
- Interfaced Order Code
- UOW156