Antibody Titer RBC IgG or Allo Antibody

General Information

Lab Name

Ab Titer RBC IgG or Allo Ab

Lab Code

ABTIGG

Epic Name

Antibody Titer RBC IgG or Allo Antibody

Description

Indications: Determination of the titer of clinically significant IgG (non-ABO) antibodies present in the patient’s plasma.

Test information: This test is most often performed on the plasma of pregnant women which contains an antibody(ies) implicated in causing Hemolytic Disease of the fetus and newborn (HDFN). Serial, two-fold dilutions of serum are tested against red cells carrying the antigen of interest (e.g., D, K) using the indirect antiglobulin method. Result is expressed as the reciprocal of the highest serum dilution which still shows (1+) agglutination. This test is used to monitor serum alloantibody levels in previously sensitized pregnant women for prenatal management of hemolytic disease of the newborn (HDN).Testing may be repeated at intervals throughout the pregnancy to monitor for a significant increase in titer. In women with Rh alloimmunization, anti-D levels greater or equal to 16 are generally considered an indication for invasive fetal testing.

Synonyms

Red blood cell alloantibody, Red cell antibody titer

Components

Code	Name
%AS	Antibody Screen
TTR	Antibody Titer