Toll Like Receptor Function (Sendout)

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General Information

Lab Name
Lab Code
981
External Test Id
0051589
Description

Ordering Recommendation: Assist in diagnosis of innate immunodeficiencies when genetic defects of the innate immune system are suspected in individuals negative for other immunodeficiencies (eg, no detectable abnormality of antibody function, complement activity, neutrophil function, or cell-mediated immunity).

Note: This test requires the collection of a control specimen from a healthy individual unrelated to the patient at approximately the same time and under similar conditions to the patient. Providers must schedule testing by contacting the Lab Medicine Resident on-call. The LMR will coordinate with the provider to arrange for an appropriate control.

Short Stability Notification: To ensure that samples arrive within the stability window for setup at ARUP, they should be sent same day as collection. Draw Monday through Thursday only; samples must be received in lab by 2 p.m. for same-day shipment.

Synonyms
0051589, TLR, Toll Like Receptor
Components

Interpretation

Method

Cell Culture/Quantitative Multiplex Bead Assay

Reference Range
Ref. Range Notes

See report.

Ordering & Collection

Specimen Type
Blood
Collection

10 mL blood in DARK GREEN TOP (Sodium Heparin) top tube for patient AND 10 mL blood in DARK GREEN TOP (Sodium Heparin) tube for control

Also Accepted: 10 mL blood in Yellow (ACD Solution A) top tube [Patient] AND 10 mL blood in Yellow (ACD Solution A) top tube [Control]

Clearly indicate "Patient" or "Control" on the sample labels.

  • For the control sample, ARUP will accept either a Sunquest-generated patient label with "Control Sample" clearly written in Sharpie to distinguish from the patient sample, or a separate hand-written label that reads, "Control Sample for [Patient Name] [Patient MRN]."

Collection Limitations:

  • Draw Monday - Thursday only.
  • Expedite transport to the lab. Samples must be in lab by 2 p.m. for same-day shipment to ARUP.
Approval Required
Laboratory Medicine Resident approval is required.
Quantity
Requested: 10 mL NaHep whole blood [Patient] AND 10 mL NaHep whole blood [Control]
Minimum: 7 mL NaHep whole blood [Patient] AND 7 mL mL NaHep whole blood [Control] (Pediatric Minimum: 3mL [patient] AND 7mL [control])

Processing

Receiving Instructions

Samples are critical ambient. Transport blood at room temperature in original collection containers. Notify Sendouts immediately upon sample receipt. Same-day shipment required.

Sendouts:

  • Order ARUP test: 0051589.
  • Ensure that samples are clearly marked as "Patient" and "Control."
  • Send samples the same day as collection.

Stability: Ambient (Required): 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable.

Reject Due To:

  • Refrigerated or frozen specimens (Live cells are required.)
  • Blood collected in Yellow ACD Solution B tubes.
Misc Sendout

Performance

Lab Department
Frequency
Performed: Tue-Fri. Reported: 9-10 days from sample receipt at ARUP Laboratories.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

Billing Comments

CPTs: 86353x6; 83520x3