Phosphatidylserine Antibodies, IgG, IgM, and IgA (Sendout)

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General Information

Lab Name
Lab Code
489
External Test Id
0050905
Description

Ordering Recommendation: Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The combined IgG and IgM Phosphatidylserine test is the preferred second-line testing in seronegative APS.

References
  1. ARUP Laboratories Phosphatidylserine Antibodies, IgG, IgM, and IgA
Synonyms
0050905, Anti-Phosphatidylserine, Antiphosphatidylserine, aPS Antibodies
Components

Interpretation

Method

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Reference Range
Ref. Range Notes

Reference Intervals:

Phosphatidylserine Ab, IgG: Less than 16 GPS
Phosphatidylserine Ab, IgM: Less than 22 MPS
Phosphatidylserine Ab, IgA: Less than 20 APS

Interpretative Data:

IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

References
  1. ARUP Laboratories Phosphatidylserine Antibodies, IgG, IgM, and IgA

Ordering & Collection

Specimen Type
Blood
Collection

3 mL blood in RED TOP or GOLD SST tube
Unacceptable: any tube with anticoagulant

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 2 weeks; Frozen: 1 month; Ambient: 48 hours.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Quantity
Requested: 0.5 mL serum
Minimum: 0.3 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Sendouts:

  • Order ARUP Test: 0050905
  • Interfaced: Yes [Interface: 602; Department: ARPR]

Stability: Refrigerated (preferred): 2 weeks; Frozen: 1 month; Ambient: 48 hours.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Misc Sendout

Performance

Lab Department
Frequency
Performed: Sun, Tue, Wed, Fri, Sat. Reported: 1-4 days from sample receipt at ARUP Laboratories.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

Billing Comments

CPTs: 86148x3