Echinococcus IgG Antibody, Serum (Sendout)

Interpretation

Guidelines

• Washington DOH Notifiable Conditions

Method

Enzyme Immunoassay (EIA)

Reference Range

Ref. Range Notes

Reference Range: Negative

Interpretation:

• Negative: The absence of antibodies to Echinococcus species suggests that the individual has not been exposed to this cestode. A single negative result should not be used to rule out infection (see Limitations).
• Positive: Results suggest infection with Echinococcus. False-positive results may occur in settings of infection with other helminths or in patients with chronic immune disorders. Results should be considered alongside other clinical findings (eg, characteristic findings on imaging) and exposure history.

Interferences and Limitations

Cautions:

Depending on cyst location, individuals may not develop high enough antibody titers to be detectable by serologic assays, leading to false-negative results. Cysts localized to the lungs, central nervous system, or spleen or cysts that are senescent, calcified, or dead are associated with lower serologic reactivity.

False-positive results may occur in patients with other helminth infections, including with Taenia species, Schistosoma species, and Strongyloides. Careful correlation with imaging findings and exposure history is required.

This assay may not detect antibodies to other species of Echinococcus, including Echinococcus vogeli and Echinococcus oligarthrus, both fairly uncommon causes of hydatid disease in humans.

References

• Mayo Clinical and Interpretive Information: Echinococcus Antibody, IgG, Serum
• Washington State Notifiable Conditions: Echinococcosis

Ordering & Collection

Specimen Type

Blood

Collection

3 mL blood in RED TOP or GOLD TOP SST tube.

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic aliquot. Freeze sample at -20°C while awaiting shipment. Transport on dry ice.

Stability: Refrigerated (preferred): 14 days; Frozen: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, or heat-inactivated specimen.

Quantity

Requested: 0.5 mL serum
Minimum: 0.4 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic aliquot. Refrigerate serum.

Login: SEND1-;REFRIG

• RSNDT1: MAYOSD
• RSTYP1: SRM
• RTSRQ1: ;Echinococcus Antibody, IgG (Mayo Test ECHNG)

Sendouts:

• Order Mayo Test: ECHNG.

Stability: Refrigerated (preferred): 14 days; Frozen: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, or heat-inactivated specimen.

Misc Sendout

Performance

Lab Department

Frequency

Performed: Tuesday. Report Available: 1-7 days.

Available STAT?

No

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901

Billing & Coding

Billing Comments

CPT: 86682