Saccharomyces Cerevisiae Antibodies (Sendout)

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General Information

Lab Name
Lab Code
332
External Test Id
SCERG, SCERA
Description

Useful For:

  • Measurement of IgA and IgG anti-Saccharomyces cerevisiae antibodies as a part of a profile to aid in distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and imaging evaluations.
  • This test is not useful for determining the extent of disease in patients with inflammatory bowel disease or determining the response to disease-specific therapy including surgical resection of diseased intestine
Synonyms
ASCA, S. cerevisiae, Saccharomyces cerevisiae Antibody IgA, Saccharomyces cerevisiae Antibody IgG
Components

Interpretation

Method

Enzyme-Linked Immunosorbent Assay (ELISA)

Reference Range
Ref. Range Notes

Reference Values:

Negative:

 <20.0 RU/mL
Positive: > or =20.0 RU/mL

Interpretation: The presence of antineutrophil cytoplasmic antibodies (ANCA) in the absence of IgA and IgG anti-Saccharomyces cerevisiae antibodies (ASCA) is consistent with the diagnosis of ulcerative colitis; the presence of IgA and IgG ASCA in the absence of ANCA is consistent with Crohn disease .

Interferences and Limitations

Cautions:

Results from this test should not be exclusively relied upon to establish the diagnosis of ulcerative colitis (UC) or Crohn disease (CD) or to distinguish between these 2 diseases. Saccharomyces cerevisiae IgA and IgG antibodies (ASCA) are most useful for distinguishing between UC and CD when assessed in conjunction with antineutrophil cytoplasmic antibodies (ANCA).

Some patients with CD have detectable ANCA, and some patients with UC have detectable IgA and/or IgG ASCA. Some patients with UC or CD do not have detectable ANCA, IgA ASCA, or IgG ASCA.

Ordering & Collection

Specimen Type
Blood
Collection

3 mL Blood in RED TOP or SST Tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. If both IgA and IgG tests are ordered, provide at least 0.8 mL serum. Refrigerate serum.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, Gross lipemia, Heat-inactivated specimen. Gross icterus is acceptable.

Quantity
Requested: 0.5 mL serum per test
Minimum: 0.4 mL serum per test

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial. If both IgA and IgG tests are ordered, provide at least 0.8 mL serum. Refrigerate serum.

Login: SEND1-;REFRIG

  • RSNDT1: MAYOSD
  • RSTYP1: SRM
  • RTSRQ1: <select appropriate test below>
    • ;Saccharomyces cerevisiae Antibodies IgA & IgG (Mayo Tests SCERA, SCERG)
    • ;Saccharomyces cerevisiae Antibody IgA (Mayo Test SCERA)
    • ;Saccharomyces cerevisiae Antibody IgG (Mayo Test SCERG)

Sendouts:

  • If S. cerevisiae IgA is requested, order Mayo Test: SCERA.
  • If S. cerevisiae IgG is requested, order Mayo Test: SCERG.
  • If IgA and IgG are requested, both test codes (SCERA, SCERG) must be ordered.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, Gross lipemia, Heat-inactivated specimen. Gross icterus is acceptable.

Misc Sendout

Performance

Lab Department
Frequency
Performed: Monday - Friday. Report Available: 14 days.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901

Billing & Coding

Billing Comments

CPTs: 86671 per antibody