HLA B1502 Genotype, Carbamazepine Hypersensitivity (Sendout)
General Information
- Lab Name
- Lab Code
- 187
- External Test Id
- 2012049
- Description
Ordering Recommendation: Useful for identifying individuals of Asian ancestry who are at risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis when administered carbamazepine (tegretol) therapy. The frequency of the HLA-B*1502 allele varies throughout Asia: 10% to 15% frequency in Chinese, 2% to 4% frequency in Southeast Asians, including Indians, and <1% frequency in Japanese and Koreans. Recommended for patients not currently taking CBZ.
- References
- ARUP Consult Topic: Germline Pharmacogenetics - PGx
- Synonyms
- 2012049, HLA-B*1502, HLA-B1502, HLAB-1502, HLAB1502, Tegretol Hypersensitivity Test
- Components
Interpretation
- Method
Polymerase Chain Reaction/Sequence Specific Oligonucleotide Probe Hybridization
- Reference Range
- Ref. Range Notes
See report.
- Interferences and Limitations
Limitations: Copy number of HLA-B*15:02 allele will not be reported.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
5 mL blood in LAVENDER TOP (EDTA) or YELLOW TOP (ACD Solution A or B) tube
- Handling Instructions
Outside Laboratories: Refrigerate whole blood while awaiting shipment. Transport with a cold pack.
Stability: Refrigerated (preferred): 7 days; Ambient: 72 hours; Frozen: Unacceptable.
Unacceptable Conditions: Specimens collected in sodium or lithium heparin.
- Quantity
-
Requested: 5 mL EDTA or ACD whole blood
Minimum: 3 mL EDTA or ACD whole blood
Processing
- Receiving Instructions
Refrigerate unspun whole blood.
Sendouts:
- Order ARUP Test: 2012049
- Interfaced: Yes [Interface: 602; Department: ARPR]
Stability: Refrigerated (preferred): 7 days; Ambient: 72 hours; Frozen: Unacceptable.
Unacceptable Conditions: Specimens collected in sodium or lithium heparin.
- Misc Sendout
Performance
- Lab Department
- Frequency
- Performed: Monday through Friday. Report Available: 3-7 days from sample receipt at ARUP Laboratories.
- Available STAT?
- No
- Performing Location(s)
-
Sendout ARUP Laboratories, Inc.
800-522-2787500 Chipeta Way
Salt Lake City, UT 84108
Billing & Coding
- Billing Comments
CPT: 81381