Movement Disorder, Autoimmune/Paraneoplastic Evaluation, CSF (Sendout)
General Information
- Lab Name
- Lab Code
- 1087
- External Test Id
- MDC2
- Description
Useful For: Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, brainstem encephalitis, chorea, dyskinesias, myoclonus, and parkinsonism using spinal fluid specimens.
Testing Algorithm: Reflex testing may be performed at additional charge. Refer to Mayo's algorithm below.
Patient Preparation: For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication, or corticosteroid or intravenous immunoglobulin (IVIg) treatment.
Ordering Requirements: Laboratory Medicine Resident (LMR) approval is required.
- Synonyms
- Ataxia, Brainstem encephalitis, Chorea, Dyskinesias, MDC2, Myoclonus, Parkinsonism
Interpretation
- Method
Panel and reflex tests include the following methods: Immunofluorescence assay (IFA), Cell-binding assay (CBA), Western blot (WB), Radioimmunoassay (RIA), Immunoblot (IB)
- Ref. Range Notes
Reference Ranges: See report.
Interpretation: A positive antibody result is consistent with a diagnosis of an autoimmune movement disorder. A search for cancer may be indicated, depending on the antibody profile. A trial of immune therapy may bring about improvement in neurological symptoms.
- Interferences and Limitations
Cautions:
A negative antibody test result does not exclude an autoimmune movement disorder.
Corticosteroid treatment prior to the cerebrospinal fluid (CSF) collection may cause a false-negative result.
Intravenous immunoglobulin treatment prior to the CSF collection may cause a false-positive result.
- Guidelines
Ordering & Collection
- Specimen Type
- CSF
- Collection
-
Collect 4 mL CSF in a sterile vial.
- Approval Required
- Laboratory Medicine Resident (LMR) approval is required.
- Handling Instructions
Outside Laboratories: Refrigerate CSF in a sterile vial.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
- Quantity
-
requested: 4 mL CSF
minimum: 3.5 mL CSF
Processing
- Processing
Refrigerate CSF in a sterile vial.
Login: SEND1-;REFRIG
- RSNDT1: MAYO
- RSTYP1: CSF
- RTSRQ1: ;Movement Disorder, Autoimmune Paraneoplastic Evaluation, CSF (Mayo Test MDC2)
Sendouts:
- Order Mayo Test: MDC2.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Performance
- LIS Dept Code
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901 - Frequency
- Performed: Monday - Sunday. Report Available: 8 - 12 days.
- Available STAT?
- No
Billing & Coding
- CPT codes
- Billing Comments
Panel CPTs: 86596, 86255x25, 84182, 86341
If indicated, reflex testing may be performed at additional charge.
- LOINC