Movement Disorder, Autoimmune/Paraneoplastic Evaluation, CSF (Sendout)
General Information
- Lab Name
- Lab Code
- 1087
- External Test Id
- MDC2
- Description
Useful For: Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, brainstem encephalitis, chorea, dyskinesias, myoclonus, and parkinsonism using spinal fluid specimens. Refer to Autoimmune Encephalitis Testing Recommendations for additional ordering guidance.
Testing Algorithm: Reflex testing may be performed at additional charge. Refer to Mayo's algorithm linked below.
Patient Preparation: For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication, or corticosteroid or intravenous immunoglobulin (IVIg) treatment.
- Synonyms
- Adaptor Protein 3 Beta2 Antibody, AGNA-1, AMPA-R Antibody CBA, Amphiphysin Antibody, ANNA-1, ANNA-2, ANNA-3, Anti-Glial Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 2, Anti-Neuronal Nuclear Antibody Type 3, AP3B2 IFA, Ataxia, Brainstem encephalitis, CASPR2 IgG CBA, Chorea, Collapsin Response-Mediator Protein-5 IgG Western Blot, Contactin-Associated Protein-Like-2 IgG, CRMP-5 IgG Western Blot, Dipeptidyl Aminopeptidase-Like Protein 6, DPPX Antibody CBA, Dyskinesias, GABA-B-R Antibody CBA, GAD65 Antibody Assay, Gamma Aminobutyric Acid Receptor Type B, GFAP IFA, Glial Fibrillary Acidic Protein Antibody, Glutamic Acid Decarboxylase Antibody, GRAF1 IFA, GTPase regulator associated with focal adhesion kinase-1, IgLON Family Member 5 Antibody, IgLON5 CBA, ITPR1 IFA, Kelch-Like Protein 11 Antibody, KLHL11 Ab CBA, Leucine-Rich Glioma Inactivated Protein-1 IgG, LGI1 IgG CBA, MDC2, Metabotropic Glutamate Receptor 1 Antibody, mGluR1 Ab IFA, Movement Disorder Autoimmune Paraneoplastic Evaluation, Myoclonus, N-methyl-D-Aspartate Receptor Antibody, Neurochondrin IFA, Neuronal Intermediate Filament Antibody, NIF IFA, NMDA-R Ab CBA, Parkinsonism, PCA-1, PCA-2, PCA-Tr, PDE10A IFA, Phosphodiesterase 10A Antibody, Purkinje Cell Cytoplasmc Antibody Type 1, Purkinje Cell Cytoplasmc Antibody Type 2, Purkinje Cell Cytoplasmc Antibody Type Tr, Septin-5 IFA, Septin-7 IFA, TRIM46 IFA, Tripartite Motif-containing Protein 46 Antibody
Interpretation
- Method
Panel and reflex tests include the following methods: Immunofluorescence assay (IFA), Cell-binding assay (CBA), Western blot (WB), Radioimmunoassay (RIA), Immunoblot (IB)
- Ref. Range Notes
Reference Ranges:
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor (AMPA-R) Antibody CBA, CSF: Negative Amphiphysin Antibody, CSF: Negative Anti-Glial Nuclear Antibody Type 1 (AGNA-1), CSF: Negative Anti-Neuronal Nuclear Antibody Type 1 (ANNA-1), CSF: Negative Anti-Neuronal Nuclear Antibody Type 2 (ANNA-2), CSF: Negative Anti-Neuronal Nuclear Antibody Type 3 (ANNA-3), CSF: Negative Adaptor Protein 3 Beta2 (AP3B2) Antibody IFA, CSF: Negative Contactin-Associated Protein-Like-2 (CASPR2) IgG Antibody CBA, CSF: Negative Collapsin Response-Mediator Protein-5 (CRMP-5) IgG Antibody WB, CSF: Negative Dipeptidyl Aminopeptidase-Like Protein 6 (DPPX) Antibody CBA, CSF: Negative Gamma Aminobutyric Acid Receptor Type B (GABA-B-R) Antibody CBA, CSF: Negative Glutamic Acid Decarboxylase (GAD65) Antibody Assay, CSF: < or =0.02 nmol/L Glial Fibrillary Acidic Protein (GFAP) Antibody IFA, CSF: Negative GTPase regulator associated with focal adhesion kinase-1 (GRAF1) Antibody IFA, CSF: Negative IgLON Family Member 5 (IgLON5) Antibody CBA, CSF: Negative Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) Antibody IFA, CSF: Negative Kelch-Like Protein 11 (KLHL11) Antibody CBA, CSF: Negative Leucine-Rich Glioma Inactivated Protein-1 IgG (LGI1) Antibody CBA, CSF: Negative Metabotropic Glutamate Receptor 1 (mGluR1) Antibody IFA, CSF: Negative Neurochondrin Antibody IFA, CSF: Negative Neuronal Intermediate Filament (NIF) Antibody IFA, CSF: Negative N-methyl-D-Aspartate Receptor (NMDA-R) Antibody CBA, CSF: Negative Purkinje Cell Cytoplasmic Antibody Type Tr, CSF (PCA-Tr): Negative Purkinje Cell Cytoplasmic Antibody Type 1, CSF (PCA-1): Negative Purkinje Cell Cytoplasmic Antibody Type 2, CSF (PCA-2): Negative Phosphodiesterase 10A (PDE10A) Antibody IFA, CSF: Negative Septin-5 Antibody IFA, CSF: Negative Septin-7 Antibody IFA, CSF: Negative Tripartite Motif-containing Protein 46 (TRIM46) Antibody IFA, CSF: Negative Note: Includes reference values for panel tests only.
Neuron-restricted patterns of IgG staining that do not fulfill criteria for ANNA-1, ANNA-2, ANNA-3, CRMP-5-IgG, PCA-1, PCA-2, or PCA-Tr may be reported as "unclassified anti-neuronal IgG." Complex patterns that include nonneuronal elements may be reported as "uninterpretable."
Interpretation: A positive antibody result is consistent with a diagnosis of an autoimmune movement disorder. A search for cancer may be indicated, depending on the antibody profile. A trial of immune therapy may bring about improvement in neurological symptoms.
- Interferences and Limitations
Cautions:
A negative antibody test result does not exclude an autoimmune movement disorder.
Corticosteroid treatment prior to the cerebrospinal fluid (CSF) collection may cause a false-negative result.
Intravenous immunoglobulin treatment prior to the CSF collection may cause a false-positive result.
- Guidelines
Ordering & Collection
- Specimen Type
- CSF
- Collection
-
Collect 4 mL CSF in a sterile vial.
- Preferred: Collection Vial Number 1
- Approval Required
- LMR approval is not required.
- Handling Instructions
Outside Laboratories: Refrigerate CSF in a sterile vial.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
- Quantity
-
requested: 4 mL CSF
minimum: 2 mL CSF
Processing
- Processing
Refrigerate CSF in a sterile vial.
Login: SEND1-;REFRIG
- RSNDT1: MAYO
- RSTYP1: CSF
- RTSRQ1: ;Movement Disorder, Autoimmune Paraneoplastic Evaluation, CSF (Mayo Test MDC2)
Sendouts:
- Order Mayo Test: MDC2
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Performance
- LIS Dept Code
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901 - Frequency
- Performed: Monday - Sunday. Report Available: 8 - 12 days from sample receipt at performing lab.
- Available STAT?
- No
Billing & Coding
- CPT codes
- Billing Comments
Panel CPTs: 86255x26, 84182, 86341, 0432U
If indicated, reflex testing may be performed at additional charge.
- LOINC