Striated Muscle IgG Antibodies with Reflex to Titer (Sendout)

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General Information

Lab Name
Lab Code
1014
External Test Id
0050746
Description

Ordering Recommendation: Recommended for differential evaluation of neuromuscular junction diseases including myasthenia gravis (MG).

Interpretive Data: When detected in the presence of acetylcholine receptor (AChR) antibody, striated muscle antibodies, which bind in a cross-striational pattern to skeletal and heart muscle tissue sections, are associated with late-onset myasthenia gravis (MG). Striated muscle antibodies recognize epitopes on three major muscle proteins, including: titin, ryanodine receptor (RyR) and Kv1.4 (an alpha subunit of voltage-gated potassium channel [VGKC]). Isolated cases of striated muscle antibodies may be seen in patients with certain autoimmune diseases, rheumatic fever, myocardial infarction, and following some cardiotomy procedures.

Note: If striated muscule antibodies are detected, a titer will be performed at additional cost.

Synonyms
0050746, Anti-Skeletal Muscle IgG Antibodies, Anti-Striated Antibody, Anti-Striated Muscle Antibody, Muscle (Skeletal) Antibodies, Myoid Antibody, Skeletal Muscle Antibodies, STM R, Striated Muscle Antibody, Striational Antibodies
Components

Interpretation

Method

Semi-Quantitative Indirect Fluorescent Antibody

Reference Range
Ref. Range Notes
Reference Interval: <1:40

Ordering & Collection

Specimen Type
Blood
Collection

Collect 3 mL blood in GOLD SST or RED TOP tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum while awaiting shipment. Transport with a cold pack.

Stability: Refrigerated (preferred): 2 weeks; Frozen: 1 year, Ambient: 48 hours.

Unacceptable Conditions: Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Quantity
Requested: 1 mL serum
Minimum: 0.15 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial within 2 hours of collection. Refrigerate serum.

Sendouts:

  • Order ARUP Test: 0050746
  • Interfaced: Yes [Interface: 602; Department: ARPR]

Stability: Refrigerated (preferred): 2 weeks; Frozen: 1 year, Ambient: 48 hours.

Unacceptable Conditions: Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Misc Sendout

Performance

Lab Department
Frequency
Performed: Monday - Saturday. Reported: 1-4 days.
Available STAT?
No
Performing Location(s)
Sendout ARUP Laboratories, Inc.
800-522-2787

500 Chipeta Way
Salt Lake City, UT 84108

Billing & Coding

Billing Comments

CPTs:

  • Striated Muscle Ab, IgG: 86255
  • Striated Muscle Ab, IgG Titer (if performed): 86256