Cryoglobulin Identification

General Information

Lab Name
Cryoglobulin ID
Lab Code
CRYIDG
Epic Name
Cryoglobulin ID
Description

If Cryoglobulin is present in sufficient quantities to perform an ID, a Cryoglobulin ID will be ordered with additional charge.

This assay characterizes the immunoglobulins present in the cryoglobulin cryoprecitate. The 3 types of cryoglobulins are differentiated by the types of immunoglobulins present in the complexes (type 1 = monoclonal, type 2 = mixed monoclonal + polyclonal, and type 3 = polyclonal), and are associated with different clinical conditions.

Components

Interpretation

Method

Immunofixation

Reference Range
See individual components
Interferences and Limitations

Testing can only be performed on samples with at least 50 uL of cryoprecipitate.

Ordering & Collection

Specimen Type
Blood
Collection

15 mL blood in RED TOP tube.

Specimen must be maintained at 37°C after collection.

Handling Instructions

Keep sample warm and transport to lab IMMEDIATELY. Suggest transporting specimen maintained at 37°C, possibly under your arm with specimen tube securely enclosed in a specimen transport bag. Specimen will be rejected if clotted. Not to be drawn on blood draw rounds.

Quantity
Requested: 5 mL serum
Minimum: 5 mL serum

Processing

Receiving Instructions

UW-MT Instructions:

Specimen MUST be kept at 37°C until received by COAG Lab. COAG: Put "unclotted" specimen in 37°C waterbath to clot for 1-2 hours to prevent CRYOGLOBULINS from being trapped in clot. After clotting is complete, spin & aliquot serum while serum is still warm. Return sample to the refrigerator in SPS. Do Not Freeze.

HMC Instructions:

Specimen MUST be kept at 37°C until received by SPS. SPS will put "unclotted" specimen in 37°C waterbath to clot for 1-2 hours to prevent CRYOGLOBULINS from being trapped in clot. After clotting is complete, spin & aliquot serum while serum is still warm. Refrigerate serum. Do not freeze.

Outside Lab Instructions:

Specimen MUST be kept at 37°C until recieved in the lab. The lab will put "unclotted" specimen in 37°C waterbath to clot for 1-2 hours to prevent CRYOGLOBULINS from being trapped in clot. If a waterbath is not available, a 37°C heat block is acceptable. After clotting is complete, spin & aliquot serum while serum is still warm. Refrigerate serum. Do Not Freeze.

Misc Sendout

Performance

Lab Department
Immunology(IMM)
Frequency
run weekly as needed,Monday-Friday dayshift only
Available STAT?
No
Performing Location(s)
UW-MT Immunology
206-520-4600

Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195

Billing & Coding

CPT Codes
82595
LOINC
48638-1
Interfaced Order Code
UOW2760